采用两步法合成N,N,N-三甲基壳聚糖季铵盐,再用己酰氯改性,得到N,N,N-三甲基-O-己酰化壳聚糖季铵盐(TMHC).产物用1H NMR、FT-IR 和EA等进行表征.抗菌实验结果表明,酰化改性能有效提高壳聚糖季铵盐的抗菌活性,并且随着酰化度的提高抗菌活性增加；TMHC对革兰氏阳性菌S.aureus的抗菌活性比革兰氏阴性菌E.coli强；另外,相同浓度(50mmol/L)金属离子对TMHC抗菌活性的抑制作用按以下顺序递减:Ba2+ ＞Ca2+ ＞Mg2+,而同一金属离子(Mg2+)对TMHC抗菌活性的抑制作用则随着离子浓度的增加而增加.
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