在组织创伤修复中，常需要应用传统的固定材料或组织粘合剂，虽然组织粘合剂较传统的固定材料有诸多优势，但仍然不能满足临床应用的要求。海洋生物贻贝能够分泌富含多巴的蛋白质，可在潮湿环境中牢固粘附于各种材料的表面。目前，已开展了大量关于贻贝粘附机理的研究，受此优异粘附性能的启发，国内外许多课题组开展了仿生组织粘合材料的研究，并在相关领域探索其应用。介绍了贻贝足盘粘附机理及贻贝仿生粘合材料的研究现状，并展望了该领域未来的发展方向。
The application of traditional fixed materials or tissue adhesives are usually required in tissue repai-ring.Although having numerous advantages compared to traditional approaches,tissue adhesives cannot meet the require-ment of clinical application completely.Due to proteins secreted by plaque,which contain abundant of DOPA,marine mussels are able to adhere to a variety of materials firmly in the wet condition.Up to date, amounts of studies have been carried out to reveal the mechanism of mussel.Furthermore,the biomimetic ad-hesives,which component and structure were similar to those of mussel adhesive proteins,have been developed inspired by the excellent adhesion properties of mussel plaque.In this review,the mechanisms of mussel and re-lated studies of the biomimetic adhesives were introduced.The perspective studies of biomimetic adhesive mate-rials in the future were also highlighted.
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