将聚阳离子壳聚糖(CS)与聚阴离子甲基丙烯酰氧乙基磷酰胆碱-甲基丙烯酸二元共聚物(poly (MPC-co-MA ),PMA30)进行静电复合,制备 CS/PMA30聚离子水凝胶,并用红外(IR )、扫描电镜(SEM)分别对其特征官能团、表面形貌进行表征。然后,以中性红为模型药物对CS/PMA30水凝胶的控释性能进行研究。结果表明,CS/PMA30体系是通过静电作用形成的物理交联水凝胶,对模型药物中性红具有明显的控释性和pH 值响应性。该水凝胶具有良好生物相容性有望在药物控释、组织工程等领域具有巨大的应用前景。该研究为进一步提高水凝胶的生物相容性提供了一个新的途径。
Novel polyelectrolyte hydrogels were prepared by polycation chitosan (CS)and polyanionic poly(2-methacryloyloxyethyl phosphorylcholine-co-methacrylic acid)(poly(MPC-co-MA),PMA30).The PMA30 (the actual percentages of MPC unit in PMA30 determined by 1 H-NMR was 28%)was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC)and methacrylic acid (MA).Fourier trans-form infrared spectra (FT-IR)and scanning electron microscopy (SEM)confirmed that the formation of the polyelectrolyte hydrogels was attributed to the strong electrostatic interaction between cationic groups in CS and anionic groups in PMA30.Potential applications of the hydrogels matrices in controlled drug delivery were also examined.In vitro release showed that neutral red release could be controlled by choosing the composition and pH.This facile method of fabricating CS/PMA30 hydrogels bearing phosphorylcholine groups may have poten-tial applications in the fields of drug delivery,tissue engineering,and cell culture.
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