采用聚乙烯醇为基础材料，以季铵盐壳聚糖为抗菌剂，丙三醇为辅料，采用溶液共混法制备聚乙烯醇/季铵盐壳聚糖复合水凝胶作为皮肤烫伤敷料，通过流变实验、抗菌实验、细胞实验以及动物活体实验考察复合水凝胶的综合性能。结果表明，制备的复合水凝胶具有适宜的粘度(22~35 Pa?s)，涂覆于皮肤表面呈现较好的粘附性能；对大肠杆菌和金黄色葡萄球菌均有良好的抑菌作用，同时具有优良的细胞相容性；复合水凝胶敷料对皮肤刺激极小，昆明鼠深Ⅱ度烫伤修复实验表明，凝胶敷料可有效加快创面愈合速度以及瘢痕的形成，创面愈合从一般的数周缩减至3周左右，大大缩短创面修复时间，且愈后瘢痕组织小。
PVA/quaternized chitosan composite hydrogel as artificial dressing was prepared by solution blending method,in which,PVA was served as substrate,quaternized chitosan as antibacterial agent and glycerol as ex-cipients.The combination properties of the composite hydrogel were studied via the rheological test,the anti-bacterial test,cytotoxic test and animal experiment.The results indicated that PVA/quaternized chitosan hy-drogel possessed appropriate viscosity(22-35 Pa?s),showed better adhesion performance when coated onto the skin.The composite hydrogel exhibited excellent inhibition effect to Escherichia coli and Staphylococcus aureus, caused only minimal irritation to skin and excellent cytocompatibility as well.The observations of deep Ⅱ de-gree burn repair test for Kunming mice revealed that the composite hydrogel was beneficial to healing of wound, formation of scar and shortening the healing time.
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