采用水热法成功制备了 NaYF4∶Yb3＋,Er3＋＠nSiO2＠mSiO2核壳结构上转换发光纳米粒子(upcon-version nanoparticles,UCNPs),并用叶酸对其表面进行了修饰,继而通过 TEM、XRD、FT-IR、BET 以及上转换发射光谱对其形貌、结构和光学性质进行了表征。结果表明,制备的 NaYF4∶Yb3＋,Er3＋纳米颗粒为纯立方相,表面均匀地包覆了一层SiO2,显示出明显的核-壳结构,平均粒径为80 nm,并且叶酸成功修饰在 NaYF4∶Yb3＋, Er3＋＠nSiO2＠mSiO2样品表面。在980 nm近红外光激发下,该UCNPs 具有良好的上转换发光效果,其主要发射峰位于524,541和655 nm波长处。该研究可以为开发兼具生物成像和良好载药性能的靶向药物载体提供一定的参考。
Core-shell structure NaYF4∶Yb3+,Er3+@nSiO2@mSiO2 nanoparticles were synthesized via hydro-thermal method and modified by folic acid,then the structure and luminescence property of the samples were characterized by XRD,TEM,FT-IR,BET and upconversion luminescence spectrum.The results show that the obtained nanoparticles are cubic phase and uniformly coated with a layer of transparent SiO2 ,which possess ob-vious spherical core-shell structure with average size of 80 nm.The results in present research indicate that the folic acid is successfully modified on the surface of UCNPs.The UCNPs has a good up-conversion luminescent effect and the main emission peak is located in 524,541,655 nm.This study may provide a new idea to the de-velopment of drug carrier target which possess both biological imaging and good drug loading properties.
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