采用气相扩散法制备得到含布洛芬的碳酸钙(CaCO3-IBU)微球，并通过 Pechini 工艺沉积磷酸八钙(OCP)壳层后制备得到含 IBU 的碳酸钙/磷酸八钙(CaCO3-IBU＠OCP).IBU 的添加量对 CaCO3-IBU 的物相和形貌有显著影响，这因为 IBU 的电离消耗 OH－离子，从而对 CO2气体的溶解、CO2－3离子的产生和 CaCO3-IBU的结晶行为都产生影响.在磷缓冲液(pH 值＝7．2~7．4)和 lysosome-like 缓冲液(pH 值＝4．7)中 IBU 自CaCO3-IBU＠OCP颗粒内释放的行为对溶液pH 值和OCP壳层结构(受柠檬酸、聚乙二醇及其分子量因素影响)敏感，这与IBU分子与CaCO3的作用机制及壳层内键合分子的位阻作用对IBU的扩散产生阻碍有关.
Calcium carbonate with encapsulation of ibuprofen (CaCO3-IBU)was firstly prepared by a facile va-por diffusion method,and was then coated with a shell of octacalcium phosphate (OCP)through a modified Pechini process.The phase and morphology of CaCO3-IBU were significantly varied with the amount of IBU ad-dition because the solubility of IBU after consumption of OH- ions influenced the solubility of CO2 gas,the generation of CO2-3 ions and crystallization of CaCO3-IBU.In phosphate buffered saline (pH=7.2-7.4)and lyso-some-like buffers (pH=4.7),the release behavior of IBU from CaCO3-IBU@OCP was sensitivity with the pH value of culture solution and the structure of OCP shell,which was varied with molecular weight of PEG, amount of citric acid and polyethylene glycol addition.The mechanism for the improved sustained-release profile was caused by the interaction between ibuprofen and CaCO3 ,as well as the steric hindrance of core-shell struc-tured drug delivery on the outward diffusion of IBU molecules.
参考文献
| [1] | Du, C.;Shi, J.;Zhang, L.;Cao, S..PUA/PSS multilayer coated CaCO_3 microparticles as smart drug delivery vehicles[J].Materials science & engineering, C. Materials for Biogical applications,20137(7):3745-3752. |
| [2] | Qiu, N.;Yin, H.;Ji, B.;Klauke, N.;Glidle, A.;Zhang, Y.;Song, H.;Cai, L.;Ma, L.;Wang, G.;Chen, L.;Wang, W..Calcium carbonate microspheres as carriers for the anticancer drug camptothecin[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20128(8):2634-2640. |
| [3] | Wang C;He C;Tong Z;Liu X;Ren B;Zeng F.Combination of adsorption by porous CaCO3 microparticles and encapsulation by polyelectrolyte multilayer films for sustained drug delivery.[J].International Journal of Pharmaceutics,20061/2(1/2):160-167. |
| [4] | Peng, CY;Zhao, QH;Gao, CY.Sustained delivery of doxorubicin by porous CaCO3 and chitosan/alginate multilayers-coated CaCO3 microparticles[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,20102/3(2/3):132-139. |
| [5] | Hyun Sook Lee;Tai Hwan Ha;Hyun Min Kim.Fabrication and Micropatterning of a Hybrid Composite of Amorphous Calcium Carbonate and Poly(ethylenimine)[J].Bulletin of the Korean Chemical Society,20073(3):457-462. |
| [6] | Xu AW;Antonietti M;Yu SH;Colfen H.Polymer-mediated mineralization and self-similar mesoscale-organized calcium carbonate with unusual superstructures[J].Advanced Materials,20087(7):1333-1338. |
| [7] | Dembski, S.;Rupp, S.;Gellermann, C.;Batentschuk, M.;Osvet, A.;Winnacker, A..Luminescent silicate core-shell nanoparticles: Synthesis, functionalization, optical, and structural properties[J].Journal of Colloid and Interface Science,20111(1):32-38. |
| [8] | Kong DY;Yu M;Lin CK;Liu XM;Lin J;Fang J.Sol-gel synthesis and characterization of Zn2SiO4 : Mn@SiO2 spherical core-shell particles[J].Journal of the Electrochemical Society,20059(9):H146-H151. |
| [9] | Gómez-Morales, J.;Delgado-López, J.M.;Iasco, M.;Hernández-Hernández, A.;Prat, M..Amino acidic control of calcium phosphate precipitation by using the vapor diffusion method in microdroplets[J].Crystal growth & design,201111(11):4802-4809. |
| [10] | Sun YP;Li XQ;Zhang WX;Wang HP.A method for the preparation of stable dispersion of zero-valent iron nanoparticles[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,20071/3(1/3):60-66. |
| [11] | Li, C.;Li, G.;Liu, S.;bai, J.;zhang, A..Spherical hydroxyapatite with colloidal stability prepared in aqueous solutions containing polymer/surfactant pair[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,20101/3(1/3):27-33. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%