作为一种具有特殊网络结构和功能的天然高分子材料，胶原基水凝胶已在医用敷料、药物载体、组织工程支架等生物医学领域得到了广泛应用。对近几年胶原基水凝胶的研究应用现状进行了全面综述，从胶原的结构与性能入手，着重对胶原基水凝胶的制备、结构性能表征及其在生物医学中的应用进行了阐述，同时对制备过程条件的控制对水凝胶结构性能的影响进行了重点讨论，对胶原基水凝胶的未来前景和发展重点进行了展望，有望为将来有关胶原基水凝胶的研究和应用提供数据参考。
Collagen based hydrogels have been used successfully as three-dimensional substrates and have shown promise for biomedical engineering.This article comprehensively reviews the research work carried out in the last few years on collagen based hydrogels with particular emphasis on preparation,characterization and bio-medical applications.A significant body of this work has been devoted to state the relationship between the preparation conditions and the structure and performance of products.Ultimately,this review can serve as a re-source for selection of fabrication parameters and hydrogels characterization methodologies.
参考文献
| [1] | Antoine, Elizabeth E.;Vlachos, Pavlos P.;Rylander, Marissa Nichole.Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport[J].Tissue engineering, Part B. Reviews,20146(6):683-696. |
| [2] | Yang Hu;Lan Liu;Zhipeng Gu.Modification of collagen with a natural derived cross-linker, alginate dialdehyde[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2014:324-332. |
| [3] | Hu, Y.;Liu, L.;Dan, W.;Dan, N.;Gu, Z..Evaluation of 1-ethyl-3-methylimidazolium acetate based ionic liquid systems as a suitable solvent for collagen[J].Journal of Applied Polymer Science,20134(4):2245-2256. |
| [4] | Raub CB;Unruh J;Suresh V;Krasieva T;Lindmo T;Gratton E;Tromberg BJ;George SC.Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties[J].Biophysical Journal,20086(6):2361-2373. |
| [5] | Wallace DG;Rosenblatt J.Collagen gel systems for sustained delivery and tissue engineering.[J].Advanced drug delivery reviews,200312(12):1631-1649. |
| [6] | Sheu MT;Huang JC;Yeh GC;Ho HO.Characterization of collagen gel solutions and collagen matrices for cell culture.[J].Biomaterials,200113(13):1713-1719. |
| [7] | Buchanan,C.F.;Voigt,E.E.;Szot,C.S.;Freeman,J.W.;Vlachos,P.P.;Rylander,M.N..Three-dimensional microfluidic collagen hydrogels for investigating flow-mediated tumor-endothelial signaling and vascular organization[J].Tissue engineering, Part C. Methods,20141(1):64-75. |
| [8] | Yang YL;Motte S;Kaufman LJ.Pore size variable type I collagen gels and their interaction with glioma cells.[J].Biomaterials,201021(21):5678-5688. |
| [9] | Yamamura N;Sudo R;Ikeda M;Tanishita K.Effects of the mechanical properties of collagen gel on the in vitro formation of microvessel networks by endothelial cells.[J].Tissue engineering,20077(7):1443-1453. |
| [10] | Yuping Li;Amran Asadi;Margo R. Monroe;Elliot P. Douglas.pH effects on collagen fibrillogenesis in vitro: Electrostatic interactions and phosphate binding[J].Materials science & engineering. C, Biomimetic materials, sensors and systems,20095(5):1643-1649. |
| [11] | Hoffman,A.S..Hydrogels for biomedical applications[J].Advanced drug delivery reviews,2012Suppl.(Suppl.):18-23. |
| [12] | 胡杨;林海;但卫华;刘兰;但年华.胶原基复合水凝胶的制备与表征（Ⅰ）--力学性能的响应曲面分析[J].中国皮革,2014(7):30-31. |
| [13] | 胡杨;林海;但卫华;刘兰;但年华.胶原基复合水凝胶的制备与表征（Ⅱ）--结构性能分析与生物学评价[J].中国皮革,2014(13):9-13. |
| [14] | 胡杨;崔国廉;林海;但卫华;刘兰;但年华.温敏性胶原基复合水凝胶的制备与表征[J].中国皮革,2015(5):33-36. |
| [15] | Sargeant,T.D.;Desai,A.P.;Banerjee,S.;Agawu,A.;Stopek,J.B..An in situ forming collagen-PEG hydrogel for tissue regeneration[J].Acta biomaterialia,20121(1):124-132. |
| [16] | Wei Song;David C Markel;Xin Jin;Tong Shi;Weiping Ren.Poly(vinyl alcohol)/collagen/hydroxyapatite hydrogel: properties and in vitro cellular response.[J].Journal of biomedical materials research, Part A,201211(11):3071-3079. |
| [17] | Bendtsen, Stephanie T.;Wei, Mei.Synthesis and characterization of a novel injectable alginate-collagen-hydroxyapatite hydrogel for bone tissue regeneration[J].Journal of Materials Chemistry, B. materials for biology and medicine,201515(15):3081-3090. |
| [18] | 熊月琴;何小维.胶原基医用复合水凝胶的制备及性质研究[J].现代食品科技,2009(12):1454-1457. |
| [19] | Omlor,G.W.;Nerlich,A.G.;Lorenz,H.;Bruckner,T.;Richter,W.;Pfeiffer,M.;Gühring,T..Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model[J].European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society,20129(9):1700-1708. |
| [20] | Deng C;Zhang P;Vulesevic B;Kuraitis D;Li F;Yang AF;Griffith M;Ruel M;Suuronen EJ.A collagen-chitosan hydrogel for endothelial differentiation and angiogenesis.[J].Tissue engineering, Part A,201010(10):3099-3109. |
| [21] | 池光范;侯宜;侯立中;颜炜群;杨同书.胶原-纤维蛋白混合凝胶对关节软骨细胞合成Ⅱ型胶原的影响[J].吉林大学学报(医学版),2004(4):524-526. |
| [22] | 王立春;张旗涛;张宏颖.纤维蛋白凝胶基质材料用于组织工程修复兔关节软骨缺损与Ⅰ型胶原凝胶和混合凝胶性能特征的比较[J].中国临床康复,2005(26):116-118. |
| [23] | 袁静;邱立朋;陈敬华.透明质酸/胶原蛋白/聚乙二醇复合水凝胶的研究[J].功能材料,2015(15):15052-15057. |
| [24] | 朱琳;贺健康;刘亚雄;曲晓丽;占利;李涤尘;靳忠民.琼脂糖/胶原复合水凝胶的制备及性能研究[J].西安交通大学学报,2013(10):121-126,136. |
| [25] | Saito H;Murabayashi S;Mitamura Y;Taguchi T.Characterization of alkali-treated collagen gels prepared by different crosslinkers[J].Journal of Materials Science. Materials in Medicine,20083(3):1297-1305. |
| [26] | Li Zheng;Hai Qing Lu;Hong Song Fan;Xing Dong Zhang.Reinforcement and chemical cross-linking in collagen-based scaffolds in cartilage tissue engineering: a comparative study[J].Iranian polymer journal,201311(11):833-842. |
| [27] | Changdao Mu;Ke Zhang;Wei Lin;Defu Li.Ring-opening polymerization of genipin and its long-range crosslinking effect on collagen hydrogel.[J].Journal of biomedical materials research, Part A,20132(2):385-393. |
| [28] | Janine M. Orban;Lorri B. Wilson;Jessica A. Kofroth.Crosslinking of collagen gels by transglutaminase[J].Journal of biomedical materials research, Part B. Applied biomaterials,20044(4):756-762. |
| [29] | 李燕;陈建苏;李晓霞;王伟.转谷氨酰胺酶交联胶原凝胶构建三维角膜基质[J].眼科研究,2009(10):839-843. |
| [30] | Inoue N;Bessho M;Furuta M;Kojima T;Okuda S;Hara M.A novel collagen hydrogel cross-linked by gamma-ray irradiation in acidic pH conditions[J].Journal of biomaterials science,20068(8):837-858. |
| [31] | Zhiyuan Peng;Yongqiang Shen.Study on Biological Safety of Polyvinyl Alcohol/Collagen Hydrogel as Tissue Substitute (I)[J].Polymer-Plastics Technology and Engineering,20111/3(1/3):245-250. |
| [32] | Stuart K;Panitch A.Influence of chondroitin sulfate on collagen gel structure and mechanical properties at physiologically relevant levels[J].Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies,200810(10):841-851. |
| [33] | Kreger, S.T.;Bell, B.J.;Bailey, J.;Stites, E.;Kuske, J.;Waisner, B.;Voytik-Harbin, S.L..Polymerization and matrix physical properties as important design considerations for soluble collagen formulations[J].Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies,20108(8):690-707. |
| [34] | Wolf, K.;Alexander, S.;Schacht, V.;Coussens, L.M.;von Andrian, U.H.;van Rheenen, J.;Deryugina, E.;Friedl, P..Collagen-based cell migration models in vitro and in vivo[J].Seminars in cell and developmental biology,20098(8):931-941. |
| [35] | Helary,C.;Zarka,M.;Giraud-Guille,M.M..Fibroblasts within concentrated collagen hydrogels favour chronic skin wound healing[J].Journal of tissue engineering and regenerative medicine,20123(3):225-237. |
| [36] | 雷静;刘旭昭;陈淡嫦;张永斌;汤顺清.凝胶型胶原敷料修复糖尿病皮肤缺损及促进血管再生[J].中国组织工程研究,2014(52):8456-8462. |
| [37] | 马慧军;贾赤宇;魏蓉;杨扬;张大艳.胶原蛋白凝胶促皮肤创面修复的临床研究[J].中国美容医学,2011(2):235-236. |
| [38] | Wenguang Liu;May Griffith;Fengfu LI.Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation[J].Journal of Materials Science. Materials in Medicine,200811(11):3365-3371. |
| [39] | Yuan,T.;Zhang,L.;Li,K.;Fan,H.;Fan,Y.;Liang,J.;Zhang,X..Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering[J].Journal of biomedical materials research, Part B. Applied biomaterials,20142(2):337-344. |
| [40] | Rafat M;Li F;Fagerholm P;Lagali NS;Watsky MA;Munger R;Matsuura T;Griffith M.PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering.[J].Biomaterials,200829(29):3960-3972. |
| [41] | 丁越;武志强;张力平.壳多糖-胶原凝胶构建组织工程口腔黏膜固有层[J].中国组织工程研究与临床康复,2010(25):4623-4626. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%