人工合成的羟基磷灰石(hydroxyapatite,HA)与人体硬组织的无机相成分相似,并具有良好的生物相容性、骨传导性和骨诱导性,在骨组织工程领域得到了广泛的应用及研究。在 HA 的制备过程中,晶体的成核作用、生长习性、表面形貌以及尺寸受到诸多因素的影响,从而导致 HA 的微结构变化多样。 HA 的微结构对材料的宏观理化性能及生物力学特性有着重要作用,近年来微结构调控成为 HA 材料研究中的热点。综述了制备方法、合成工艺参数、离子取代及有机物模板等对 HA微结构的调控及研究动向。
Synthetic hydroxyapatite (HA)has a chemical similarity to the inorganic component of nature bone. Due to the excellent biocompatibility,osteoconduction and osteoinduction,HA has received great attention of researchers and has been widely used in bone tissue engineering.During the synthesis processing,there are vari-ous factors that effect on the nucleation,crystal growth,morphology and crystal size of HA,resulting in pre-pared HA with different microstructure.As the microstructure has a great influence on the physical,chemical and biomechanical properties of HA,microstructure regulation for HA has become a hot research area in recent years.This review briefly addresses recent progresses of HA microstructure regulation in processing method, synthesis parameters,ion replace and organics template.The existing problems and research trends are obj ec-tively pointed out as well.
参考文献
| [1] | Yi Deng;Huanan Wang;Li Zhang;Yubao Li;Shicheng Wei.In situ synthesis and in vitro biocompatibility of needle-like nano-hydroxyapatite in agar-gelatin co-hydrogel[J].Materials Letters,2013Aug.1(Aug.1):8-12. |
| [2] | Ciobanu, C.S.;Iconaru, S.L.;Pasuk, I.;Vasile, B.S.;Lupu, A.R.;Hermenean, A.;Dinischiotu, A.;Predoi, D..Structural properties of silver doped hydroxyapatite and their biocompatibility[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20133(3):1395-1402. |
| [3] | Chen, J.;Nan, K.;Yin, S.;Wang, Y.;Wu, T.;Zhang, Q..Characterization and biocompatibility of nanohybrid scaffold prepared via in situ crystallization of hydroxyapatite in chitosan matrix[J].Colloids and Surfaces, B. Biointerfaces,20102(2):640-647. |
| [4] | Chang BS;Lee CK;Hong KS;Youn HJ;Ryu HS;Chung SS;Park KW.Osteoconduction at porous hydroxyapatite with various pore configurations.[J].Biomaterials,200012(12):1291-1298. |
| [5] | Gonda Y;Ioku K;Shibata Y.Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts.[J].Biomaterials,200926(26):4390-4400. |
| [6] | Kilian O;Wenisch S;Karnati S;Baumgart-Vogt E;Hild A;Fuhrmann R;Jonuleit T;Dingeldein E;Schnettler R;Franke RP.Observations on the microvasculature of bone defects filled with biodegradable nanoparticulate hydroxyapatite.[J].Biomaterials,200824/25(24/25):3429-3437. |
| [7] | Synthesis of nanorod and needle-like hydroxyapatite crystal and role of pH adjustment[J].Journal of Crystal Growth,200923/24(23/24):4740. |
| [8] | Komlev VS;Barinov SM;Koplik EV.A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release.[J].Biomaterials,200216(16):3449-3454. |
| [9] | Teng SH;Shi JJ;Chen LJ.A novel method to synthesize large-sized hydroxyapatite rods[J].Journal of Crystal Growth,20062(2):683-688. |
| [10] | Yingchao Han;Shipu Li;Xinyu Wang;Li Jia;Jianhua He.Preparation of hydroxyapatite rod-like crystals by protein precursor method[J].Materials Research Bulletin: An International Journal Reporting Research on Crystal Growth and Materials Preparation and Characterization,20076(6):1169-1177. |
| [11] | Viswanath B;Ravishankar N.Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone.[J].Biomaterials,200836(36):4855-4863. |
| [12] | Mayo Uehira;Masahiro Okada;Shoji Takeda;Naoyuki Matsumoto.Preparation and characterization of low-crystallized hydroxyapatite nanoporous plates and granules[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,2013Dec.15(Dec.15):195-202. |
| [13] | Nejati, E;Firouzdor, V;Eslaminejad, MB;Bagheri, F.Needle-like nano hydroxyapatite/poly(L-lactide acid) composite scaffold for bone tissue engineering application[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20093(3):942-949. |
| [14] | Kamitakahara, M.;Imai, R.;Ioku, K..Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20134(4):2446-2450. |
| [15] | Kaili Lin;Peiyi Liu;Li Wei.Strontium substituted hydroxyapatite porous microspheres: Surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release[J].Chemical engineering journal,2013:49-59. |
| [16] | Nagano M.;Kokubo T.;Tanahashi M.;Ogawa M.;Nakamura T..DIFFERENCES OF BONE BONDING ABILITY AND DEGRADATION BEHAVIOUR IN VIVO BETWEEN AMORPHOUS CALCIUM PHOSPHATE AND HIGHLY CRYSTALLINE HYDROXYAPATITE COATING[J].Biomaterials,199618(18):1771-1777. |
| [17] | Balasundaram G;Sato M;Webster TJ.Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD[J].Biomaterials,200614(14):2798-2805. |
| [18] | Liu C;Huang Y;Shen W;Cui J.Kinetics of hydroxyapatite precipitation at pH 10 to 11.[J].Biomaterials,20014(4):301-306. |
| [19] | Shan Gao;Kangning Sun;Aimin Li;Hongyou Wang.Synthesis and characterization of hydroxyapatite nanofiber by chemical precipitation method using surfactants[J].Materials Research Bulletin: An International Journal Reporting Research on Crystal Growth and Materials Preparation and Characterization,20133(3):1003-1006. |
| [20] | Renu Sharma;Ravi Ranjan Pandey;Anubha A. Gupta;Satabhisa Kar;Marshal Dhayal.In situ amino acid functionalization and microstructure formation of hydroxyapatite nanoparticles synthesized at different pH by precipitation route[J].Materials Chemistry and Physics,20122/3(2/3):718-725. |
| [21] | Ronghai Zhu;Ranbo Yu;Jianxi Yao.Morphology control of hydroxyapatite through hydrothermal process[J].Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics,20081/2(1/2):555-559. |
| [22] | Guodong Zhang;Jingdi Chen;Shen Yang;Qifeng Yu;Zhili Wang;Qiqing Zhang.Preparation of amino-acid-regulated hydroxyapatite particles by hydrothermal method[J].Materials Letters,20113(3):572-574. |
| [23] | Hai-bin Zhang;Ke-chao Zhou;Zhi-you Li;Su-ping Huang.Plate-like hydroxyapatite nanoparticles synthesized by the hydrothermal method[J].The journal of physics and chemistry of solids,20091(1):243-248. |
| [24] | Jung-Hee Lee;Young-Jin Kim.Hydroxyapatite nanofibers fabricated through electrospinning and sol-gel process[J].CERAMICS INTERNATIONAL,20142(2):3361-3369. |
| [25] | Zhang L;Li YB;Yang AP;Peng XL;Wang XJ;Zhang X.Preparation and in vitro investigation of chitosan/nano-hydroxyapatite composite used as bone substitute materials[J].Journal of Materials Science. Materials in Medicine,20053(3):213-219. |
| [26] | Vial S;Prevot V;Forano C.Novel route for layered double hydroxides preparation by enzymatic decomposition of urea[J].The journal of physics and chemistry of solids,20065/6(5/6):1048-1053. |
| [27] | Hongxia Zhao;Hua Jin;Jiye Cai.Preparation and characterization of nano-hydroxyapatite/chitosan composite with enhanced compressive strength by urease-catalyzed method[J].Materials Letters,2014Feb.1(Feb.1):293-295. |
| [28] | K. Madhumathi;K.T. Shalumon;V.V. Divya Rani;H. Tamura;T. Furuike;N. Selvamurugan;S.V. Nair;R. Jayakumar.Wet chemical synthesis of chitosan hydrogel-hydroxyapatite composite membranes for tissue engineering applications[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,20091(1):12-15. |
| [29] | Atsushi Matsuda;Mayumi Kasahara;Hisatoshi Kobayashi;Noboru Ichinose;Junzo Tanaka.Compounding of hydroxyapatite crystals to molecularly aligned crab tendon chitosan: the effect of heat treatment[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20046/8(6/8):717-722. |
| [30] | Baskar, D.;Balu, R.;Kumar, T.S..Mineralization of pristine chitosan film through biomimetic process[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,20113(3):385-389. |
| [31] | Cassiano G. Aimoli;Marco A. Torres;Marisa M. Beppu.Investigations into the early stages of 'in vitro' calcification on chitosan films[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20061(1):78-86. |
| [32] | 韩颖超;王欣宇;李世普.纳米级磷灰石粉末制备工艺进展[J].硅酸盐通报,2002(3):27-29. |
| [33] | 郭广生;王颖;王志华;郭洪猷.化学沉淀法制备羟基磷灰石纳米粒子[J].化学通报(印刷版),2004(11):830-834. |
| [34] | 石和彬;钟宏;刘羽;田兴;顾金燕;杨昌盛.共沉淀法制备纳米羟基磷灰石[J].化学与生物工程,2012(8):16-20. |
| [35] | 杨辉;王栋;蔡日强.共沉淀法制备高纯度纳米羟基磷灰石的研究[J].精细化工,2010(1):5-10. |
| [36] | 梁琼;韩冬梅;顾福博;王志华;郭广生.水热重结晶法制备羟基磷灰石纳米棒[J].无机化学学报,2007(1):86-90. |
| [37] | 张爱娟.溶-凝胶法制备纳米羟基磷灰石的研究进展[J].材料工程,2006(z1):463-465. |
| [38] | M.H. Fathi;A. Hanifi.Evaluation and characterization of nanostructure hydroxyapatite powder prepared by simple sol-gel method[J].Materials Letters,200718(18):3978-3983. |
| [39] | Feray Bakan;Oral Lacin;Hanifi Sarac.A novel low temperature sol-gel synthesis process for thermally stable nano crystalline hydroxyapatite[J].Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems,2013:295-302. |
| [40] | R.M. Trommer;LA. Santos;C.P. Bergmann.Nanostructured hydroxyapatite powders produced by a flame-based technique[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20096(6):1770-1775. |
| [41] | George C.Koumoulidis;Alexandros.P.Katsoulidis;Athanasios K.Laavos;Phillippos J.Pomonis;Antonios T.Sdoukos.Preparation of hydroxyapatite via microemulsion route[J].Journal of Colloid and Interface Science,20032(2):254-260. |
| [42] | G. GUO;Y. SUN;Z. WANG.Preparation of hydroxyapatite nanoparticles by reverse microemulsion[J].Ceramics International,20056(6):869-872. |
| [43] | Kaili Lin;Jiang Chang;Rongming Cheng.Hydrothermal microemulsion synthesis of stoichiometric single crystal hydroxyapatite nanorods with mono-dispersion and narrow-size distribution[J].Materials Letters,20078/9(8/9):1683-1687. |
| [44] | 江昕;韩颖超;李世普;阎玉华.快速均匀沉淀法制备纳米级HAP粉末[J].硅酸盐通报,2002(1):44-46. |
| [45] | 资文华;孙俊赛;陈庆华;郭旭侠;丑修建.纳米羟基磷灰石制备工艺的最新研究进展[J].昆明理工大学学报(理工版),2003(4):23-26. |
| [46] | Qian Sun;Jin-Ting Lou;Fang Kang.Facile preparation of hydroxyapatite nanotubes assisted by needle-like calcium carbonate[J].Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems,2014:49-54. |
| [47] | 仇满德;代爱梅;杨盼;李旭;牛苗;白国义.水热体系中不同的前驱物对羟基磷灰石微结构的影响?[J].功能材料,2015(19):19024-19027. |
| [48] | 冯杰;曹洁明;邓少高.纳米结构羟基磷灰石的微波固相合成新方法[J].无机化学学报,2005(6):801-804. |
| [49] | 郭英;李酽;李乐.水热条件下羟基磷灰石纳米晶形成机理[J].中国民航大学学报,2007(4):26-30. |
| [50] | Jing Zhao;Ying-Jie Zhu;Guo-Feng Cheng;Yin-Jie Ruan;Tuan-Wei Sun;Feng Chen;Jin Wu;Xin-Yu Zhao;Guan-Jun Ding.Microwave-assisted hydrothermal rapid synthesis of amorphous calcium phosphate nanoparticles and hydroxyapatite microspheres using cytidine 5′-triphosphate disodium salt as a phosphate source[J].Materials Letters,2014Jun.1(Jun.1):208-211. |
| [51] | 郭大刚;付涛;徐可为.短棒状纳米羟基磷灰石的湿法合成及表征[J].硅酸盐学报,2002(2):189-192. |
| [52] | Jin, Xiaoying;Chen, Xiaohu;Cheng, Yute;Wang, Longshen;Hu, Bing;Tan, Junjun.Effects of hydrothermal temperature and time on hydrothermal synthesis of colloidal hydroxyapatite nanorods in the presence of sodium citrate[J].Journal of Colloid and Interface Science,2015:151-158. |
| [53] | Yousefpour, M.;Taherian, Z..The effects of ageing time on the microstructure and properties of mesoporous silica-hydroxyapatite nanocomposite[J].Superlattices and microstructures,2013:78-86. |
| [54] | Bigi A;Boanini E;Capuccini C;Gazzano M.Strontium-substituted hydroxyapatite nanocrystals[J].Inorganica Chimica Acta,20073(3):1009-1016. |
| [55] | Chen Wei;Huang Zhiliang;Liu Yu.Preparation and characterization of a novel solid base catalyst hydroxyapatite loaded with strontium[J].Catalysis Communications,20084(4):516-521. |
| [56] | 王端诚;颜廷亭;黄明华;朱维波;陈庆华.掺镁羟基磷灰石晶须的制备与研究[J].人工晶体学报,2014(3):648-651. |
| [57] | Gunjan Verma;K.C. Barick;N. Manoj.Rod-like micelle templated synthesis of porous hydroxyapatite[J].CERAMICS INTERNATIONAL,20138(8):8995-9002. |
| [58] | 周琰春;蔡玉荣;刘丽;刘玉侃;张铭;章燕珍.球形羟基磷灰石纳米颗粒的可控合成及其对间充质干细胞生长分化的影响[J].无机化学学报,2007(8):1335-1340. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%