以天然纤维素纸张材料为基材，通过氧气低温等离子体技术在其表面接枝抗凝血药物肝素，以提高该类材料的血液相容性。对表面化学接枝肝素纸样的体外凝血时间测试、红细胞形态观察、全血和血小板粘附实验等血液相容性评价结果表明，与未改性原纸相比，表面化学接枝肝素的纸样的体外凝血时间 APTT、PT 和 TT值都显著增加，抗溶血和血小板、血细胞粘附的能力都明显改善。通过 pNPP 法对表面化学接枝肝素纸张负载VEGF的行为及其对 HUVEC存活、增殖的影响进行了评价，表明 Paper-Hep 纸样由于其对 VEGF 的长期控释作用，对 HUVEC的存活及增殖更为有益。
The surface of cellulose-based paper was grafted with heparin anticoagulants by oxygen low tempera-ture plasma technology in order to improve its blood compatibility.The results of assess to blood compatibility shows that paper grafted with heparin has higher anticoagulation than original paper.Comparing with original paper the value of APTT,PT and TT of the heparin grafted paper has been remarkably extended and at the same time its performance of anti-hemolysis and anti-adhesion to platelets and blood cells has been improved ob-viously.The performance of heparin grafted paper in loading VEGF and its influence to the survival and prolif-eration of HUVEC has been also evaluated by pNPP.For the long-term controlled release to the VEGF paper grafted with heparin is more helpful to the survival and proliferation of HUVEC.
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