研究了Ce3+对原代肝细胞内cAMP和cGMP的影响,并测定了用Ce3+长期喂养的大白鼠脏器肝、肾、脾、肾上腺中cAMP和cGMP的含量.结果表明,Ce3+能使原代肝细胞内cAMP和cGMP浓度显著增加.长期喂养Ce3+的大白鼠肝、肾中cAMP含量上升,脾、肾上腺中cAMP含量降低;肝、肾中cGMP含量降低,脾、肾上腺中cGMP浓度上升.结果提示Ce3+可能通过影响第二信使系统而产生一系列的生理效应.
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