交联壳聚糖吸附剂对多肽的吸附性能

材料科学与工艺, 2004, 12(3): 234-237. doi: 10.3969/j.issn.1005-0299.2004.03.003

交联壳聚糖吸附剂对多肽的吸附性能

张明明 ^1, , 王虹 ^2, , 刘韬 ^3, , 付国旗 ^4, , 袁直 ^5, , 何炳林 ^6,

1.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

2.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

3.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

4.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

5.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

6.南开大学高分子化学研究所吸附分离功能高分子材料国家重点实验室,天津,300071

基金项目: 教育部青年基金国家自然科学基金(59873011) 国家重点基础研究发展计划(973计划)(G 1999064707)

关键词：尿毒症 , 中分子 , 壳聚糖 , 吸附剂 , 多肽

Adsorption of peptides by crosslinked chitosan adsorbent

为了研究血液灌流用多肽吸附剂以治疗尿毒症,本文以戊二醛为交联剂,用反向悬浮聚合方法制备了交联壳聚糖吸附剂,继而用NaBH4还原处理,并对其还原效果和溶胀性能作了表征.吸附实验结果表明,吸附剂对选取的六种多肽均有不同程度的吸附;随着多肽链的增长,吸附剂对其的吸附能力体现出先增强后减小的趋势;对分子量为1 100的垂体后叶素吸附效果最好.同时,吸附动力学曲线表明,随着肽分子量的增大,达到吸附平衡的时间也延长,对六种肽的吸附分别在0.6～2 h内达到平衡.

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