以较少量(质量分数4%)的国产商品化钯/炭为催化剂,在温度160℃,压力0.60～O.70 MPa条件下,由4-(反式-4'-正戊基环己基)苯酚加氢合成了4-(反式-4'-正戊基环己基)环己酮,酚的转化率为97.1%,酮的选择性为85.5%,加以高锰酸钾氧化进行后处理,少量原料酚可直接氧化去除,醇则氧化为目标酮,总收率85.2%.该反应体系催化剂用量较少,且安全与环保.
参考文献
| [1] | Heinz L,Alexander K,Eberhard Z,et al.Process for preparing substituted cyclohexanones:US,5886232[P].1999-3-23. |
| [2] | 李娟利,安忠维.侧向氟取代双烷基环己基联苯类液晶化合物的介晶性研究[J].液晶与显示,2006,21(3):214-217. |
| [3] | Shigeru S,Tetsuhiko K,Masakazu T.Liquid-crystalline halogenobenzene derivatives:US,4405488[P].1983-9-20. |
| [4] | 杨建明,吕剑,安忠维.4-正戊基环己酮的合成[J].合成化学,2003,11(1):49-51. |
| [5] | 丁翼,纪柱,李国安,等.铬化合物生产与应用[M].北京:化学工业出版社,2002:10-11. |
| [6] | Hiroyuki M,Takeshi Y.Perfume composition:US,4888323[P].1989-12-19. |
| [7] | Michio H,Shigeo N.Studies concerning the factors affecting the formation of cyclohexanone intermediates in the catalytic hydrogenation of phenols.I.Hydrogenation of p-cresol over various Pd-C catalysts I-J].Bull.Chem.Soc.Jpn.,1992,65(3):824-830. |
| [8] | Michio H,Shigeo N.Effects of alcoholic solvents on the formation of cyclohexanones in the hydrogenation of phenols over Pd-C catalysts[J].Bull.Chem.Soc.Jpn.,1992,65(11):2955-2959. |
| [9] | Wolfgang K.Verfahren zur herstellung von cyclohexanonen durch hydrierung der entsprechenden phenole in gegenwart von alkanen als losungsmittel:DE,19727710[P].1997-1-30. |
| [10] | Norimoto K,Shinsaku K,Kenji E,et al.Process for producing alicyclic monoketones and process for producing alicyclic diketones:US,6313351[P].2001-11-6. |
| [11] | Benrd O,Peter M,Detlef P,et al.Process for the preparation of cyclohexanones:US,6215028[P].2001-4-10. |
| [12] | Wydra M,Vogel H.Selective hydrogenation of 4-substituted phenol derivatives to cyclohexanone analogs.Catalyst optimization and kinetics[J].Chemie Ingenieur Technik,2002,74(6):800-804. |
| [13] | 杨永忠,高仁孝,刘鸿.4-丙基环己酮新合成方法[J].化学试剂,2005,27(1):47-48. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%