试剂的有效混合是化学和生化反应的前提条件,因此混合成为微全分析系统的重要功能单元.本文介绍了一种通道中集成氧化铟锡(ITO)电极的聚二甲基硅氧烷(PDMS)-玻璃复合混沌混合芯片的快速制备方法,对PDMS的混合通道表面进行了硅溶胶改性.首次用集成的电极和酸碱反应过程中的电导变化对其混合效果进行了评价.利用玻璃各向同性刻蚀特点,一次曝光和一次刻蚀得到了混沌混合微通道结构的母板.利用光辅助原位聚合的方法快速制备了与母板微结构互补的聚甲基丙烯酸甲酯(PMMA)阳模,利用PI)MS原位聚合的方法复制得到了与玻璃母板结构相同的混沌混合通道结构的芯片.用电导法对芯片的混合有效性进行了表征.PDMS复制芯片与ITO玻璃永久封合即得全透明的复合混沌混合芯片.本文介绍的加工方法无需二次曝光及SU-8光刻胶,容易多次复制,在微流控分析芯片中将有广泛应用.
参考文献
| [1] | Manz A;Graber N;Widmer HM .Miniaturized total chemical analysis systems:A novel concept for chemical sensing[J].Sensors and Actuators B:Chemical,1990,1(06):244-248. |
| [2] | Dirk B#kenkamp;Amish Desai;Xing Yang .Microfabricated Silicon Mixers for Submillisecond Quench-Flow Analysis[J].Analytical chemistry,1998(2):232-236. |
| [3] | Vijayendran RA.;Motsegood KM.;Beebe DJ.;Leckband DE. .Evaluation of a three-dimensional micromixer in a surface-based biosensor[J].Langmuir: The ACS Journal of Surfaces and Colloids,2003(5):1824-1828. |
| [4] | S. Freitas;A. Walz;H. P. Merkle;B. Gander .Solvent extraction employing a static micromixer: a simple, robust and versatile technology for the microencapsulation of proteins[J].Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres,2003(1):67-85. |
| [5] | Stroock AD;Derringer SKW;Ajdari A et al.Chaotic Mixer for Microchannels[J].Science,2002,295(5555):647-651. |
| [6] | Sato H;Ito S;Tajima K;Orimoto N;Shoji S .PDMS microchannels with slanted grooves embedded in three walls to realize efficient spiral flow[J].Sensors and Actuators, A. Physical,2005(2):365-371. |
| [7] | Johnson TJ.;Ross D.;Locascio LE. .Rapid microfluidic mixing[J].Analytical chemistry,2002(1):45-51. |
| [8] | Aubin J;Fletcher DF;Xuereb C .Design of micromixers using CFD modelling[J].Chemical Engineering Science,2005(8/9):2503-2516. |
| [9] | Matthew S.Munson;Paul Yager .Simple quantitative optical method for monitoring the extent of mixing applied to a novel microfluidic mixer[J].Analytica chimica acta,2004(1):63-71. |
| [10] | Roman GT;Hlaus T;Bass KJ;Seelhammer TG;Culbertson CT .Sol-gel modified poly(dimethylsiloxane) microfluidic devices with high electroosmotic Mobilities and hydrophilic channel wall characteristics[J].Analytical chemistry,2005(5):1414-1422. |
| [11] | 吴志勇;方芳;张娜 等.一种混沌混合芯片的微加工[P].CNl811421 |
| [12] | Alexander Muck;Joseph Wang;Michael Jacobs;Gang Chen;Madhu Prakash Chatrathi;Vlastimil Jurka;Zdenek Vyborny;Scott D. Spillman;Gautham Sridharan;Michael J. Schoning .Fabrication of Poly(methyl methacrylate) Microfluidic Chips by Atmospheric Molding[J].Analytical chemistry,2004(8):2290-2297. |
| [13] | Chen G;Li JH;Qu S;Chen D;Yang PY .Low temperature bonding of poly(methylmethacrylate) electrophoresis microchips by in situ polymerisation[J].Journal of chromatography, A: Including electrophoresis and other separation methods,2005(1/2):138-147. |
| [14] | Yevgeny Berdichevsky;Julia Khandurina;Andras Guttman;Y.-H. Lo .UV/ozone modification of poly(dimethylsiloxane) microfluidic channels[J].Sensors and Actuators, B. Chemical,2004(2/3):402-408. |
| [15] | 吴志勇,方芳,关艳霞,王世立,徐章润,方肇伦.微流控芯片电导检测系统研究[C].第三届全国微全分析系统学术会议论文集,2005:86-87. |
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