利用近红外光谱(Near infrared spectrum,NIRS)测量技术进行射频损毁术中实时监测技术研究,探讨立体定向术中损毁疗效评估的可行性.在进行丘脑腹外侧核(Ventrolateral Thalamus,Vim)毁损术射频损毁的同时,使用近红外光谱实时采集系统检测在损毁过程中吸收系数(μa)与优化散射系数(μ's)的变化情况.结果表明: 44℃射频损毁过程中吸收系数和优化散射系数增大,停止掀毁后逐步恢复,稳定后μa和μ's稍高于初始值; 70℃射频损毁时μz和μ's增大,停止损毁且稳定后保持不变.根据μa和μ's的变化规律进行立体定向毁损过程实时监测是非常有可能的.
参考文献
| [1] | Markolf H N,Zhang Zhengxi,transl.Laser-Tissue Interactions:Fundamentals and Applications[M].Xi'an:Xi'an Jiaotong Universtiy Press,1999.9-18. |
| [2] | Huang Lan,Tian Fenghua,Ding Haishu,et al.The study of methods for measurement tissue oxygenation by using NIRS[J].J.Infrared Milim Waves (红外与毫米波报),2003,22(5):379-383 (in Chinese). |
| [3] | van Veen R L P,Sterenborg H J C M,Pifferi A,et al.Determination of VIS-NIR absorption coefficients of mammalian fat,with time and spatially resolved diffuse reflectance and transmission spectroscopy[C].J.Biomed.Opt.,2005,10(5):054004. |
| [4] | Li Rong,Qian Zhiyu,Dai Lijuan.Automatic measurement system of NIR spectrum of biological tissue based on virtual instruments[J].Computer Measurement and Control (计算机测量与控制),2007,15(2):154-156 (in Chinese). |
| [5] | Qian Zhiyu,Victor S S,Gu Yueqing,et al." Look-Ahead distance " of a fiber probe used to assist neurosurgery:plantom and monte carlo study[J].Optics Express,2003,11(16):1844-1856. |
| [6] | Qian Zhiyu,Gu Yueqing,Liu Hanli.In vivo and real time measurement of rat brain reduced scattering coefficient (μ's)[J].Chinese Journal of Medical Physics (中国医学物理学杂志),2005,22:463-465 (in Chinese). |
| [7] | Qian Zhiyu.Study of near infrared guidance technique for 3D targeted localization in neuro-surgery for parkin-son's disease (chapter 4 and 5)[D].Nanjing:Doctoral Dissertation of Nanjing University of Aeronautics and Astronautics,2003,37-61. |
| [8] | Wei Huajiang,Xing Da,He Bohua,et al.Canceration and thermal coagulation of human liver induced changes in the absorption and scattering properties of liver-tissue at near-infrared in vitro[J].Spectroscopy and Spectral Analysis (光谱学与光谱分析),2007,5(27):868-872 (in Chinese). |
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