本文采用乳化交联法制备了可附载放射性核素的磁靶向药物载体-磁性壳聚糖复合微球.考察了壳聚糖浓度、Fe3O4/壳聚糖质量比及搅拌速度等因素对磁性壳聚糖微球粒径、粒径分布以及形貌等对复合过程的影响,确定了制备高磁响应性的磁性壳聚糖的最佳条件,并借助不同手段对磁性壳聚糖的粒径、粒径分布、形貌及磁性能进行了初步表征.
参考文献
| [1] | WidderKJ;Senyei A E;Ranney D F .[J].Advances in Pharmacology and Chemotherapy,1979,16:213-268. |
| [2] | GuptaPK;HungCT .[J].Life Sciences,1989,44:175-186. |
| [3] | MoldayRS;Mackenzie D .[J].Journal of Immunological Methods,1982,52:353-367. |
| [4] | CarlsenJE;MollerM L;Lund J O .[J].Nuclear Medicine,1980,21:121-129. |
| [5] | HafeliUO;Roberts W K;Pauer G J;Kraeft S K, Macklis R M .[J].Applied Radiation and Isotopes,2001,54:869-879. |
| [6] | Hafeli UO;Sweeney SM;Beresford BA;Humm JL;Macklis RM .Effective targeting of magnetic radioactive 90Y-microspheres to tumor cells by an externally applied magnetic field. Preliminary in vitro and in vivo results.[J].Nuclear Medicine and Biology,1995(2):147-155. |
| [7] | HafeliUO;Pauer G et al.[J].Journal of Magnetism and Magnetic Materials,2001,225:73-78. |
| [8] | MathiowitzE;Langer R .[J].Control Release,1987,5:13-22. |
| [9] | Gruttner C.;Teller J.;Rudershausen S. .Improved properties of magnetic particles by combination of different polymer materials as particle matrix[J].Journal of Magnetism and Magnetic Materials,2001(1/2):1-7. |
| [10] | GruttnerC;Teller J;Schutt W;Westphal F Schumichen C Paulke B R.[M].Scientific and Clinical Application of Magnetic Carriers,Rostock,Germany,1996,9,New York London:Plenum Press,1997 |
| [11] | Hertzog;Mottl T;Yim D;Mathiowitz E.Scientific and Clinical Application of Magnetic Carriers Rostock Germany 19969[M].New York London:Plenum Press,1997:77-92. |
| [12] | SchuttW;Gruttner C;Teller J et al.[J].Artificial Organs,1999,23(01):98-103. |
| [13] | CalvoP;Lopez C R;Jato J L;Alonso M J .[J].Pharmaceutical Research,1997,14(10):1431-1436. |
| [14] | DenkasE;Kilicay E;Birlikseven C;Ozturk E .[J].Reactive and Functional Polymers,2002,50:225-232. |
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