通过原子转移自由基聚合(ATRP)制备了聚(丙烯酸叔丁酯-b-甲基丙烯酸二甲胺基乙酯)(PtBA-b-PDMAEMA)两亲性嵌段共聚物,在共溶剂THF溶液中加入选择性溶剂水自组装制备了Pt-BA-b-PDMAEMA胶束.以1,2-二(2-碘乙氧烷)乙烷(BIEE)为交联剂与PDMAEMA发生交联反应,制备了壳交联胶束(SCL胶束).通过核磁共振(1H-NMR)、动态光散射(DLS)和透射电镜(TEM)研究了壳交联胶束的结构和形态,并详细探讨了BIEE和PDMAEMA的摩尔比对壳交联结构的影响.发现当[BIEE]/[PDMAEMA]小于0.5时,易发生胶束内交联,形成球形胶束；当其大于0.5时,倾向于形成胶束之间的交联,导致其流体力学直径的增加.另外,还研究了壳交联胶束的pH和温度响应性,发现随着温度和pH的变化,SCL胶束表现出可逆的收缩-伸展性,可以作为药物控制释放的良好载体.
参考文献
| [1] | Lowe A;McCormick C.Synthesis and Solution Properties of Zwitterionic Polymers[J].Chemical Reviews,2002(102):4177-4190. |
| [2] | Matyjaszewski K;Tsarevsky N.Nanostroctured Functional Materials Prepared by Atom Transfer Radical Polymerization[J].NatureChem,2009(01):276-288. |
| [3] | Gerard Riess .Micellization of block copolymers[J].Progress in Polymer Science,2003(7):1107-1170. |
| [4] | J.Rodriguez-Hernandez;F.Checot;Y.Gnanou;S.Lecommandoux .Toward 'smart' nano-objects by self-assembly of block copolymers in solution[J].Progress in Polymer Science,2005(7):691-724. |
| [5] | Jiang, XZ;Zhang, GY;Narain, R;Liu, SY .Covalently stabilized temperature and pH responsive four-layer nanoparticles fabricated from surface 'clickable' shell cross-linked micelles[J].Soft matter,2009(7):1530-1538. |
| [6] | Fenghua Meng;Zhiyuan Zhong;Jan Feijen .Stimuli-Responsive Polymersomes for Programmed Drug Delivery[J].Biomacromolecules,2009(2):197-209. |
| [7] | Sakai K;Vamvakaki M;Smith EG;Wanless EJ;Armes SP;Biggs S .Adsorption characteristics of zwitterionic diblock copolymers at the silica/aqueous solution interface[J].Journal of Colloid and Interface Science,2008(2):383-394. |
| [8] | Cyrille Boyer;Michael R. Whittaker;Kyloon Chuah;Jingquan Liu;Thomas P. Davis .Modulation of the Surface Charge on Polymer-Stabilized Gold Nanoparticles by the Application of an External Stimulus[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(4):2721-2730. |
| [9] | Liu SY.;Weaver JVM.;Tang YQ.;Billingham NC.;Armes SP.;Tribe K. .Synthesis of shell cross-linked micelles with pH-responsive cores using ABC triblock copolymers[J].Macromolecules,2002(16):6121-6131. |
| [10] | Remsen Edward E.;Wooley Karen L.;Thurmond K. Bruce II .Solution and surface charge properties of shell cross-linked knedel nanoparticles[J].Macromolecules,1999(11):3685-3689. |
| [11] | Kozo Matsumoto;Tetsuo Hirabayashi;Tamotsu Harada;Hideki Matsuoka .Synthesis of Shell Cross-Linked Block Copolymer Micelles with Poly(p-styrenesulfonic acid) in the Micelle Core[J].Macromolecules,2005(24):9957-9962. |
| [12] | Jiang, X.;Zhang, G.;Narain, R.;Liu, S. .Fabrication of two types of shell-cross-linked micelles with "inverted" structures in aqueous solution from schizophrenic water-soluble ABC triblock copolymer via click chemistry[J].Langmuir: The ACS Journal of Surfaces and Colloids,2009(4):2046-2054. |
| [13] | Smith, AE;Xu, XW;Abell, TU;Kirkland, SE;Hensarling, RM;McCormick, CL .Tuning Nanostructure Morphology and Gold Nanoparticle "Locking" of Multi-Responsive Amphiphilic Diblock Copolymers[J].Macromolecules,2009(8):2958-2964. |
| [14] | Bo Xu;Jinfang Yuan;Tao Ding .Amphiphilic biodegradable poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) triblock copolymers: synthesis, characterization and their use as drug carriers for folic acid[J].Polymer bulletin,2010(6):537-551. |
| [15] | Yuk SH.;Lee SH.;Cho SH. .PH/TEMPERATURE-RESPONSIVE POLYMER COMPOSED OF POLY((N,N-DIMETHYLAMINO)ETHYL METHACRYLATE-CO-ETHYLACRYLAMIDE)[J].Macromolecules,1997(22):6856-6859. |
| [16] | Butun V;Lowe A;Billingham N.Synthesis of Zwitterionic Shell Cross-Linked Micelles[J].Journal of the American Chemical Society,1999(121):4288-4289. |
| [17] | Butun V.;Banez MVD.;Robinson KL.;Billingham NC.;Armes SP. Tuzar Z.;Wang XS. .Synthesis of shell cross-linked micelles at high solids in aqueous media[J].Macromolecules,2000(1):1-3. |
| [18] | Qu, T.;Wang, A.;Yuan, J.;Gao, Q. .Preparation of an amphiphilic triblock copolymer with pH- and thermo-responsiveness and self-assembled micelles applied to drug release[J].Journal of Colloid and Interface Science,2009(2):865-871. |
| [19] | Chang, C;Wei, H;Feng, J;Wang, ZC;Wu, XJ;Wu, DQ;Cheng, SX;Zhang, XZ;Zhuo, RX .Temperature and pH Double Responsive Hybrid Cross-Linked Micelles Based on P(NIPAAm-co-MPMA)-b-P(DEA): RAFT Synthesis and "Schizophrenic" Micellization[J].Macromolecules,2009(13):4838-4844. |
| [20] | Xiaoze Jiang;Shiyong Liu;Ravin Narain .Degradable Thermoresponsive Core Cross-Linked Micelles: Fabrication,Surface Functionalization, and Biorecognition[J].Langmuir: The ACS Journal of Surfaces and Colloids,2009(23):13344-13350. |
| [21] | Zhang ZG.;Bell S.;Lin GJ. .Synthesis of poly(solketal methacrylate)-block-poly(2-(dimethylamino)ethyl methacrylate) and preparation of nanospheres with cross-linked shells[J].Macromolecules,2000(21):7877-7883. |
| [22] | Elizabeth S. Read;Steven P. Armes .Recent advances in shell cross-linked micelles[J].Chemical communications,2007(29):3021-3035. |
| [23] | Butun V.;Armes SP.;Billingham NC. .Unusual aggregation behavior of a novel tertiary amine methacrylate-based diblock copolymer: Formation of micelles and reverse micelles in aqueous solution[J].Journal of the American Chemical Society,1998(45):11818-11819. |
| [24] | Vanessa Schmidt;Redouane Borsali;Cristiano Giacomelli .Aggregation of a Versatile Triblock Copolymer into pH-Responsive Cross-Linkable Nanostructures in Both Organic and Aqueous Media[J].Langmuir: The ACS Journal of Surfaces and Colloids,2009(23):13361-13367. |
| [25] | Njikang G;Han DH;Wang J;Liu GJ .ABC Triblock Copolymer Micelle-Like Aggregates in Selective Solvents for A and C[J].Macromolecules,2008(24):9727-9735. |
| [26] | Zhang, X.;Ai, C.;Ma, J.;Xu, J.;Yang, S. .Synthesis of zwitterionic shell cross-linked micelles with pH-dependent hydrophilicity[J].Journal of Colloid and Interface Science,2011(1):24-30. |
| [27] | Adam E. Smith;Xuewei Xu;Charles L. McCormick .Stimuli-responsive amphiphilic(co)polymers via RAFT polymerization[J].Progress in Polymer Science,2010(1/2):45-93. |
| [28] | Adam E. Smith;Xuewei Xu;Stacey E. Kirkland-York;Daniel A. Savin;Charles L. McCormick .“Schizophrenic” Self-Assembly of Block Copolymers Synthesized via Aqueous RAFT Polymerization: From Micelles to Vesicles[J].Macromolecules,2010(3):1210-1217. |
| [29] | Wei Chen;Fenghua Meng;Ru Cheng;Zhiyuan Zhong .pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(1):40-46. |
| [30] | Shun Wan;Ming Jiang;Guangzhao Zhang .Dual Temperature- and pH-Dependent Self-Assembly of Cellulose-Based Copolymer with a Pair of Complementary Grafts[J].Macromolecules,2007(15):5552-5558. |
| [31] | Liu, X.;Ni, P.;He, J.;Zhang, M. .Synthesis and micellization of pH/temperature-responsive double-hydrophilic diblock copolymers polyphosphoester- block -poly[2-(dimethylamino)ethyl methacrylate] prepared via ROP and ATRP[J].Macromolecules,2010(10):4771-4781. |
| [32] | Shinji Sugihara;Steven P. Armes;Andrew L. Lewis .One-Pot Synthesis of Biomimetic Shell Cross-Linked Micelles and Nanocages by ATRP in Alcohol/Water Mixtures[J].Angewandte Chemie,2010(20):3500-3503. |
| [33] | Li Xu;Zhichen Zhu;Oleg V. Borisov;Ekaterina B. Zhulina;Svetlana A. Sukhishvili .pH-Triggered Block Copolymer Micelle-to-Micelle Phase Transition[J].Physical review letters,2009(11):118301.1-118301.4. |
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