树状大分子是一类高度支化的单分散性大分子,具有精确可控的分子结构.本文在树状大分子结构特点的基础上,阐述了以树状大分子为载体的新型纳米CT成像造影剂的合成及其在CT成像中的应用,并对树状大分子在CT成像中的发展趋势和应用领域进行了展望.
参考文献
| [1] | Peer D;Karp JM;Hong S;FaroKHzad OC;Margalit R;Langer R .Nanocarriers as an emerging platform for cancer therapy[J].Nature nanotechnology,2007(12):751-760. |
| [2] | Moghimi S M;Hunter A C;Murray J C .Nanomedicine:current status and future prospects[J].Federation of America Societies for Experimental Biology Journal,2005,19(03):311-330. |
| [3] | Tomalia D A;Baker H;Dewald J et al.A new class of polymers:starburst-dendritic macromoleeules[J].Polymer Journal,1985,17(01):117-132. |
| [4] | Flory P J .Molecular size distribution in three dimensional polymers.Ⅰ gelationl[J].Journal of the American Chemical Society,1941,63(11):3083-3090. |
| [5] | Boas U;Christensen J B;Heegaard P M H.Dendrimers in Medicine and Biotechnology:New Molecular Tools[M].Royal Society of Chemistry,2006 |
| [6] | Weissleder R .Molecular imaging: exploring the next frontier (editorial)[J].Radiology,1999(3):609-614. |
| [7] | Debbage P;Jaschke W .Molecular imaging with nanoparticles: giant roles for dwarf actors.[J].Histochemistry and cell biology,2008(5):845-875. |
| [8] | Deshpande N;Needles A;Willmann JK .Molecular ultrasound imaging: current status and future directions.[J].Clinical Radiology,2010(7):567-581. |
| [9] | Krause W .Delivery of diagnostic agents in computed tomography[J].Advanced Drug Delivery Reviews,1999,37(1-3):159-173. |
| [10] | Haller C;Hizoh I .The cytotoxicity of iodinated radiocontrast agents on renal cells in vitro.[J].Investigative radiology,2004(3):149-154. |
| [11] | Alexander T. Yordanov;Adriana L. Lodder;Eric K. Woller;Nicholas Patronas;Diane Milenic;Martin W. Brechbiel .Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging[J].Nano letters,2002(6):595-599. |
| [12] | Yordanov A T;Mollov N;Lodder A L et al.A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging[J].Journal of the Serbian Chemical Society,2005,70(02):163-170. |
| [13] | Yanjun Fu;Danute E.Nitecki;David Maltby .Dendritic Iodinated Contrast Agents with PEG-Cores for CT Imaging:Synthesis and Preliminary Characterization[J].Bioconjugate Chemistry,2006(4):1043-1056. |
| [14] | Guo R;Wang H;Peng C et al.Enhanced X ray attenuation property of dendrimer-entrapped gold nanoparticles complexed with diatrizoic acid[J].Journal of Materials Chemistry,2011,18(13):5120-5127. |
| [15] | Rui Guo;Han Wang;Chen Peng .X-ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2010(1):50-56. |
| [16] | Peng, C.;Wang, H.;Guo, R.;Shen, M.;Cao, X.;Zhu, M.;Zhang, G.;Shi, X. .Acetylation of dendrimer-entrapped gold nanoparticles: Synthesis, stability, and X-ray attenuation properties[J].Journal of Applied Polymer Science,2011(3):1673-1682. |
| [17] | Peng C;Zheng L;Chen Q;Shen M;Guo R;Wang H;Cao X;Zhang G;Shi X .PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography.[J].Biomaterials,2012(4):1107-1119. |
| [18] | Wang H;Zheng L;Peng C;Guo R;Shen M;Shi X;Zhang G .Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles.[J].Biomaterials,2011(11):2979-2988. |
| [19] | Marc R.Knecht;Joaquin C.Garcia-Martinez;Richard M.Crooks .Hydrophobic Dendrimers as Templates for Au Nanoparticles[J].Langmuir: The ACS Journal of Surfaces and Colloids,2005(25):11981-11986. |
| [20] | Oh SK.;Kim YG.;Ye HC.;Crooks RM. .Synthesis, characterization, and surface immobilization of metal nanoparticles encapsulated within bifunctionalized dendrimers[J].Langmuir: The ACS Journal of Surfaces and Colloids,2003(24):10420-10425. |
| [21] | Xiangyang Shi;Inhan Lee;James R. Baker Jr .Acetylation of dendrimer-entrapped gold and silver nanoparticlest[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2008(5):586-593. |
| [22] | Shi XG;Wang SH;Meshinchi S;Van Antwerp ME;Bi XD;Lee IH;Baker JR .Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and Imaging[J].Small,2007(7):1245-1252. |
| [23] | Shi X Y;Wang S H;Sun H P et al.Improved biocompatibility of surface functionalized dendrimer entrapped gold nanoparticles[J].Soft Matter,2007,3(01):71-74. |
| [24] | Richard M.Crooks;Mingqi Zhao;Li Sun;Victor Chechik;Lee K.Yeung .Dendrimer-Encapsulated Metal Nanoparticles:Synthesis, Characterization, and Applications to Catalysis[J].Accounts of Chemical Research,2001(3):181-190. |
| [25] | Balogh L.;Tomalia DA. .Poly(amidoamine) dendrimer-templated nanocomposites. 1. Synthesis of zerovalent copper nanoclusters[J].Journal of the American Chemical Society,1998(29):7355-7356. |
| [26] | Balogh L;Valluzzi R;Laverdure K S et al.Formation of silver and gold dendrimer nanocomposites[J].J NanoparticleRes,1999,1:353-368. |
| [27] | Lemon BI.;Crooks RM. .Preparation and characterization of dendrimer-encapsulated CdS semiconductor quantum dots[J].Journal of the American Chemical Society,2000(51):12886-12887. |
| [28] | Orla M.Wilson;Robert W.J.Scott;Joaquin C.Garcia-Martinez;Richard M.Crooks .Synthesis,Characterization,and Structure-Selective Extraction of 1-3-nm Diameter AuAg Dendrimer-Encapsulated Bimetallic Nanoparticles[J].Journal of the American Chemical Society,2005(3):1015-1024. |
| [29] | Esumi K .Dendrimers for nanoparticle synthesis and dispersion stabilization[J].Colloid Chemistry Ⅱ,2003,227:31-52. |
| [30] | Nalwa H S .Encyclopedia Nanoscience and Nanotechnology[J].American Scientific Publisher,2004,2:317-326. |
| [31] | Esumi K.;Aihara N.;Usui K.;Torigoe K.;Suzuki A. .Preparation of gold colloids with UV irradiation using dendrimers as stabilizer[J].Langmuir: The ACS Journal of Surfaces and Colloids,1998(12):3157-3159. |
| [32] | Esumi K.;Yamahira A.;Torigoe K.;Suzuki A. .Role of poly(amidoamine) dendrimers for preparing nanoparticles of gold, platinum, and silver[J].Langmuir: The ACS Journal of Surfaces and Colloids,2000(6):2604-2608. |
| [33] | Amir Fahmi;Torsten Pietsch;Dietmar Appelhans .Water-soluble CdSe nanoparticles stabilised by dense-shell glycodendrimers[J].New Journal of Chemistry,2009(4):703-706. |
| [34] | Xiangyang Shi;T Rose Ganser;Kai Sun .Characterization of crystalline dendrimer-stabilized gold nanoparticles[J].Nanotechnology,2006(4):1072-1078. |
| [35] | Shi XY;Sun K;Baker JR .Spontaneous formation of functionalized dendrimer-stabilized gold nanoparticles[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2008(22):8251-8258. |
| [36] | X SHI;K SUN;L P BALOGH .Synthesis, characterization, and manipulation of dendrimer-stabllized iron sulfide nanoparticles[J].Nanotechnology,2006(18):4554-4560. |
| [37] | Satoh N;Nakashima T;Kamikura K;Yamamoto K .Quantum size effect in TiO2 nanoparticles prepared by finely controlled metal assembly on dendrimer templates[J].Nature nanotechnology,2008(2):106-111. |
| [38] | T. Goodson;O. Varnavski;Y. Wang .Optical properties and applications of dendrimer-metal nanocomposites[J].International Reviews in Physical Chemistry,2004(1):109-150. |
| [39] | X.C.Wu;A.M.Bittner;K.Kern .Synthesis,Photoluminescence,and Adsorption of CdS/Dendrimer Nanocomposites[J].The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical,2005(1):230-239. |
| [40] | Kojima, C.;Umeda, Y.;Ogawa, M.;Harada, A.;Magata, Y.;Kono, K. .X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer.[J].Nanotechnology,2010(24):245104-1-245104-6. |
| [41] | Hui Liu;Han Wang;Rui Guo .Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications[J].Polymer chemistry,2010(10):1677-1683. |
| [42] | Liu, H.;Shen, M.;Zhao, J.;Guo, R.;Cao, X.;Zhang, G.;Shi, X..Tunable synthesis and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy nanoparticles[J].Colloids and Surfaces, B. Biointerfaces,2012:58-67. |
| [43] | Liu, H.;Sun, K.;Zhao, J.;Guo, R.;Shen, M.;Cao, X.;Zhang, G.;Shi, X..Dendrimer-mediated synthesis and shape evolution of gold-silver alloy nanoparticles[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2012:22-29. |
| [44] | Celeste Aida S. Regino;Stuart Walbridge;Marcelino Bernardo .A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents[J].Contrast media & molecular imaging,2008(1):2-8. |
| [45] | Cai H;Li K;Shen M et al.Facile assembly of Fea O4@Au nanocomposite particles for dual mode magnetic resonance and computed tomography imaging applications[J].Journal of Materials Chemistry,2012,22(30):15110-15120. |
| [46] | Shukla, R;Hill, E;Shi, XY;Kim, J;Muniz, MC;Sun, K;Baker, JR .Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles[J].Soft matter,2008(11):2160-2163. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%