抗生素及其抗性基因（ ARGs）是环境中普遍存在的新兴污染物，其环境水平和分布特征等相关研究方兴未艾。本文在总结大量文献的基础上，着重阐述了我国环境多介质中抗生素及其ARGs分布特征的最新研究进展，介绍了抗生素的存在状况与环境水平，讨论了抗生素的浓度水平时空分布差异及其对水生环境的风险，进一步通过介绍ARGs在环境中的污染水平，评述了抗生素ARGs污染物分布特征、水平转移及相应的微生物群落结构变化，最后对这两类新兴污染物的环境分布研究进行了展望，并针对我国现状提出了今后的研究重点。
Antibiotics and antibiotic resistance genes ( ARGs ) are emerging pollutants that widely occur in the environment, so their environmental levels and distributional characteristics have recently received increasing concerns. This paper reviews the current research progress on the occurrence of antibiotics and the corresponding ARGs in the multi?environment of China. The occurrence and levels of antibiotics are introduced, and their spatial and seasonal distribution variation as well as aquatic environmental risks are discussed. Furthermore, distribution characteristics, horizontal transfer and the corresponding microbial community changes of ARGs are summarized based on their contamination levels. Finally, the research prospects about the environmental distribution of antibiotics and ARGs are proposed, and some key issues are suggested for China in the future.
参考文献
| [1] | 葛林科,张思玉,谢晴,陈景文.抗生素在水环境中的光化学行为[J].中国科学B辑,2010(02):124-135. |
| [2] | 贾瑷,胡建英,孙建仙,施嘉琛.环境中的医药品与个人护理品[J].化学进展,2009(02):389-399. |
| [3] | Watkinson, AJ;Murby, EJ;Kolpin, DW;Costanzo, SD .The occurrence of antibiotics in an urban watershed: From wastewater to drinking water[J].Science of the Total Environment,2009(8):2711-2723. |
| [4] | Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China[J].Water research: A journal of the international water association,2008(1/2):p.395-403. |
| [5] | Edhlund BL;Arnold WA;McNeill K .Aquatic photochemistry of nitrofuran antibiotics[J].Environmental Science & Technology: ES&T,2006(17):5422-5427. |
| [6] | Jose L. Martinez .Antibiotics and Antibiotic Resistance Genes in Natural Environments[J].Science,2008(5887):365-367. |
| [7] | 王丽梅,罗义,毛大庆,周启星.抗生素抗性基因在环境中的传播扩散及抗性研究方法[J].应用生态学报,2010(04):1063-1069. |
| [8] | 徐冰洁,罗义,周启星,毛大庆.抗生素抗性基因在环境中的来源、传播扩散及生态风险[J].环境化学,2010(02):169-178. |
| [9] | 贺小萌,曹罡,邵明非,李继.空气中抗性基因（ARGs）的研究方法及研究进展[J].环境化学,2014(05):739-747. |
| [10] | Ju XD;Jin YH;Sasaki K;Saito N .Perfluorinated surfactants in surface, subsurface water and microlayer from Dalian Coastal waters in China[J].Environmental Science & Technology: ES&T,2008(10):3538-3542. |
| [11] | ZHEN WANG;JINGWEN CHEN;PING YANG .Distribution of PAHs in pine (Pinus thunbergii) needles and soils correlates with their gas-particle partitioning[J].Environmental Science & Technology: ES&T,2009(5):1336-1341. |
| [12] | Hamscher G.;Sczesny S.;Hoper H.;Nau H. .Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry[J].Analytical chemistry,2002(7):1509-1518. |
| [13] | Kim SC;Carlson K .Temporal and spatial trends in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices[J].Environmental Science & Technology: ES&T,2007(26):50-57. |
| [14] | Lin Xu;Michal Rysz;Yi Luo .Occurrence and Transport of Tetracycline, Sulfonamide, Quinolone, and Macrolide Antibiotics in the Haihe River Basin, China[J].Environmental Science & Technology: ES&T,2011(5):1827-1833. |
| [15] | MANU TAMMINEN;ANTTI KARKMAN;ANDRES LOHMUS .Tetracycline Resistance Genes Persist at Aquaculture Farms in the Absence of Selection Pressure[J].Environmental Science & Technology: ES&T,2011(2):386-391. |
| [16] | Jiang, L.;Hu, X.;Xu, T.;Zhang, H.;Sheng, D.;Yin, D..Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China[J].Science of the Total Environment,2013:267-272. |
| [17] | Zhenhao Ling,Ying Yang,Yuanli Huang,Shichun Zou,Tiangang Luan.A preliminary investigation on the occurrence and distribution of antibiotic resistance genes in the Beijiang River, South China[J].环境科学学报（英文版）,2013(08):1656-1661. |
| [18] | Xiaoxuan Wei;Jingwen Chen;Qing Xie .Distinct Photolytic Mechanisms and Products for Different Dissociation Species of Ciprofloxacin[J].Environmental Science & Technology: ES&T,2013(9):4284-4290. |
| [19] | Kummerer K .Antibiotics in the aquatic environment-A review-Part I[J].CHEMOSPHERE,2009,75(4):417-434. |
| [20] | Anne L. Boreen;William A. Arnold;Kristopher McNeill .Photodegradation of pharmaceuticals in the aquatic environment: A review[J].Aquatic sciences,2003(4):320-341. |
| [21] | Chang-Er Chen;Hao Zhang;Guang-Guo Ying .Evidence and Recommendations to Support the Use of a Novel Passive Water Sampler to Quantify Antibiotics in Wastewaters[J].Environmental Science & Technology: ES&T,2013(23):13587-13593. |
| [22] | Junfeng Niu,Lilan Zhang,Yang Li,Jinbo Zhao,Sidan Lv,Keqing Xiao.Effects of environmental factors on sulfamethoxazole photodegradation under simulated sunlight irradiation: Kinetics and mechanism[J].环境科学学报（英文版）,2013(06):1098-1106. |
| [23] | Junfeng Niu;Yang Li;Wenlong Wang .Light-source-dependent role of nitrate and humic acid in tetracycline photolysis: Kinetics and mechanism[J].Chemosphere: Environmental toxicology and risk assessment,2013(11):1423-1429. |
| [24] | Yang Li;Junfeng Niu;Wenlong Wang .Photolysis of Enrofloxacin in aqueous systems under simulated sunlight irradiation: Kinetics, mechanism and toxicity of photolysis products[J].Chemosphere,2011(5):892-897. |
| [25] | LINKE GE;JINGWEN CHEN;XIANLIANG QIAO .Light-Source-Dependent Effects of Main Water Constituents on Photodegradation of Phenicol Antibiotics: Mechanism and Kinetics[J].Environmental Science & Technology: ES&T,2009(9):3101-3107. |
| [26] | Li B;Zhang T .Biodegradation and Adsorption of Antibiotics in the Activated Sludge Process[J].American Chemical Society,2010,44(9):3468-3473. |
| [27] | 杨常青,王龙星,侯晓虹,陈吉平.大辽河水系河水中16种抗生素的污染水平分析[J].色谱,2012(08):756-762. |
| [28] | Wei-hai Xu;Gan Zhang;Shi-chun Zou;Xiang-dong Li;Yu-chun Liu .Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry[J].Environmental Pollution,2007(3):672-679. |
| [29] | Tu Binh Minh;Ho Wing Leung;I. Ha Loi;Wing Hei Chan;Man Ka So;J.Q. Mao;David Choi;James C.W. Lam;Gene Zheng;Michael Martin;Joseph H.W. Lee;Paul K.S. Lam;Bruce J. Richardson .Antibiotics in the Hong Kong metropolitan area: Ubiquitous distribution and fate in Victoria Harbour[J].Marine pollution bulletin,2009(7):967-975. |
| [30] | Debska J.;Kot-Wasik A.;Namiesnik J. .Fate and analysis of pharmaceutical residues in the aquatic environment [Review][J].Critical reviews in analytical chemistry,2004(1):51-67. |
| [31] | 葛林科 .水中溶解性物质对氯霉素类和氟喹诺酮类抗生素光降解的影响[D].大连理工大学,2009. |
| [32] | 邰义萍,莫测辉,吴小莲,李彦文,苏青云,冯玉年,王纪阳,黄献培.绿色和有机蔬菜基地土壤中喹诺酮类抗生素的污染特征[J].农业环境科学学报,2012(01):125-128,130. |
| [33] | 张笑归,宁国辉,刘树庆,张铁铮,王艳群,莫测辉.张家口葡萄产区土壤抗生素含量及其潜在生态环境风险评价[J].华北农学报,2011(z1):146-151. |
| [34] | Yan-Wen Li;Xiao-Lian Wu;Ce-Hui Mo .Investigation of Sulfonamide, Tetracycline, and Quinolone Antibiotics in Vegetable Farmland Soil in the Pearl River Delta Area, Southern China[J].Journal of Agricultural and Food Chemistry,2011(13):7268-7276. |
| [35] | 王丹,隋倩,赵文涛,吕树光,邱兆富,余刚.中国地表水环境中药物和个人护理品的研究进展[J].科学通报,2014(09):743-751. |
| [36] | 王冲,罗义,毛大庆.土壤环境中抗生素的来源、转归、生态风险以及消减对策[J].环境化学,2014(01):19-29. |
| [37] | YI-LUO;DAQING MAO;MICHAL RYSZ .Trends in Antibiotic Resistance Genes Occurrence in the Haihe River, China[J].Environmental Science & Technology: ES&T,2010(19):7220-7225. |
| [38] | Ximei Liang;Baowei Chen;Xiangping Nie;Zhen Shi;Xiaoping Huang;Xiangdong Li .The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China[J].Chemosphere: Environmental toxicology and risk assessment,2013(11):1410-1416. |
| [39] | Lei Jiang;Xialin Hu;Daqiang Yin;Hongchang Zhang;Zhenyang Yu .Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River Shanghai China[J].Chemosphere: Environmental toxicology and risk assessment,2011(6):822-828. |
| [40] | Shichun Zou;Weihai Xu;Ruijie Zhang;Jianhui Tang;Yingjun Chen;Gan Zhang .Occurrence and distribution of antibiotics in coastal water of the Bohai Bay,China: Impacts of river discharge and aquaculture activities[J].Environmental Pollution,2011(10):2913-2920. |
| [41] | Hanmin Zhang;Pengxiao Liu;Yujie Feng;Fenglin Yang .Fate of antibiotics during wastewater treatment and antibiotic distribution in the effluent-receiving waters of the Yellow Sea, northern China[J].Marine pollution bulletin,2013(1):282-290. |
| [42] | Weihai Xu;Wen Yan;Xiangdong Li;Yongde Zou;Xiaoxiang Chen;Weixia Huang;Li Miao;Ruijie Zhang;Gan Zhang;Shichun Zou .Antibiotics in riverine runoff of the Pearl River Delta and Pearl River Estuary, China: Concentrations, mass loading and ecological risks[J].Environmental Pollution,2013(Nov.):402-407. |
| [43] | Ruijie Zhang;Gan Zhang;Qian Zheng;Jianhui Tang;Yingjun Chen;Weihai Xu;Yongde Zou;Xiaoxiang Chen.Occurrence and risks of antibiotics in the Laizhou Bay, China: Impacts of river discharge[J].Ecotoxicology and Environmental Safety,2012:208-215. |
| [44] | Qian Zheng;Ruijie Zhang;Yinghui Wang;Xiaohui Pan;Jianhui Tang;Gan Zhang .Occurrence and distribution of antibiotics in the Beibu Gulf, China: Impacts of river discharge and aquaculture activities[J].Marine environmental research,2012(Jul.):26-33. |
| [45] | Xiao, Y;Chang, H;Jia, A;Hu, JY .Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry[J].Journal of Chromatography. A,2008(1/2):100-108. |
| [46] | Li-Jun Zhou;Guang-Guo Ying;Jian-Liang Zhao;Ji-Feng Yang;Li Wang;Bin Yang;Shan Liu .Trends in the occurrence of human and veterinary antibiotics in the sediments of the Yellow River, Hai River and Liao River in northern China[J].Environmental Pollution,2011(7):1877-1885. |
| [47] | Lei X N;Lu J J;Liu Z L.Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang[J].ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2014:1-9. |
| [48] | NA Guangshui,GU Jia,GE Linke,ZHANG Peng,WANG Zhen,LIU Chunyang,ZHANG Lin.Detection of 36 antibiotics in coastal waters using high performance liquid chromatography-tandem mass spectrometry[J].中国海洋湖沼学报（英文版）,2011(05):1093-1102. |
| [49] | Guangshui Na;Xiaodan Fang;Yaqi Cai;Linke Ge;Humin Zong;Xiutang Yuan;Ziwei Yao;Zhifeng Zhang .Occurrence, distribution, and bioaccumulation of antibiotics in coastal environment of Dalian, China[J].Marine pollution bulletin,2013(1/2):233-237. |
| [50] | Wenhui Li;Yali Shi;Lihong Gao;Jiemin Liu;Yaqi Cai .Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China[J].Chemosphere: Environmental toxicology and risk assessment,2012(11):1307-1315. |
| [51] | Ruijie Zhang;Jianhui Tang;Jun Li;Qian Zheng;Di Liu;Yingjun Chen;Yongde Zou;Xiaoxiang Chen;Chunling Luo;Gan Zhang .Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: Occurrence, distribution and ecological risks[J].Environmental Pollution,2013(Mar.):71-77. |
| [52] | Ruicheng Wei;Feng Ge;Siyu Huang;Ming Chen;Ran Wang .Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China[J].Chemosphere: Environmental toxicology and risk assessment,2011(10):1408-1414. |
| [53] | Chen K;Zhou J L .Occurrence and behavior of antibiotics in water and sediments from the Huangpu River,Shanghai,China[J].CHEMOSPHERE,2014,95:604-612. |
| [54] | Xiajun Zhuo;Yun Guo;Changlun Tong .Occurrence and Risk Assessment of Four Typical Fluoroquinolone Antibiotics in Raw and Treated Sewage and in Receiving Waters in Hangzhou, China[J].Journal of Agricultural and Food Chemistry,2011(13):7303-7309. |
| [55] | Gulkowska A;He Y;So M K et al.The occurrence of selected antibiotics in Hong Kong coastal waters[J].Marine Pollution Bulletin,2007,54:1287-1306. |
| [56] | Yang, J.-F.;Ying, G.-G.;Zhao, J.-L.;Tao, R.;Su, H.-C.;Chen, F. .Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC-MS/MS[J].Science of the Total Environment,2010(16):3424-3432. |
| [57] | Li X W;Xie Y F;Li C L et al.Investigation of residual fluoroquinolones in a soil-vegetable system in an intensive vegetable cultivation area in Northern China[J].Science of the Total Environment,2014,468-469:258-264. |
| [58] | Xiuling Ji;Qunhui Shen;Fang Liu;Jing Ma;Gang Xu;Yuanlong Wang;Minghong Wu .Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China[J].Journal of hazardous materials,2012(Oct.15):178-185. |
| [59] | 雷炳莉,黄圣彪,王子健.生态风险评价理论和方法[J].化学进展,2009(02):350-358. |
| [60] | 周启星,罗义,王美娥.抗生素的环境残留、生态毒性及抗性基因污染[J].生态毒理学报,2007(03):243-251. |
| [61] | TIMOTHY M. LaPARA;CINDY H.NAKATSU;LISA PANTEA;JAMES E.ALLEMAN .Phylogenetic analysis of bacterial communities in mesophilic and thermophilic bioreactors treating pharmaceutical wastew ater[J].Applied and Environmental Microbiology,2000(9):3951-3959. |
| [62] | Rizzo, L.;Manaia, C.;Merlin, C.;Schwartz, T.;Dagot, C.;Ploy, M.C.;Michael, I.;Fatta-Kassinos, D..Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review (Review)[J].Science of the Total Environment,2013:345-360. |
| [63] | DAVID W. GRAHAM;SUSANA OLIVARES-RIEUMONT;CHARLES W. KNAPP .Antibiotic Resistance Gene Abundances Associated with Waste Discharges to the Almendares River near Havana, Cuba[J].Environmental Science & Technology: ES&T,2011(2):418-424. |
| [64] | 邹世春,朱春敬,贺竹梅,栾天罡,徐维海,张干.北江河水中抗生素抗性基因污染初步研究[J].生态毒理学报,2009(05):655-660. |
| [65] | 刘苗苗,张昱,李栋,李魁晓,高迎新,杨敏.制药废水受纳河流中四环素抗药基因及微生物群落结构变化研究[J].环境科学学报,2010(08):1551-1557. |
| [66] | Hong Chen;Mingmei Zhang .Effects of Advanced Treatment Systems on the Removal of Antibiotic Resistance Genes in Wastewater Treatment Plants from Hangzhou, China[J].Environmental Science & Technology: ES&T,2013(15):8157-8163. |
| [67] | 张婉茹 .大连近岸沉积物环境中典型抗生素及抗性菌株分布特征[D].大连:大连工业大学,2014. |
| [68] | Hong Chen;Mingmei Zhang .Occurrence and removal of antibiotic resistance genes in municipal wastewater and rural domestic sewage treatment systems in eastern China[J].Environment international,2013(May):9-14. |
| [69] | Feng-Hua Wang;Min Qiao;Zhen-E Lv;Guang-Xia Guo;Yan Jia;Yu-Hong Su;Yong-Guan Zhu .Impact of reclaimed water irrigation on antibiotic resistance in public parks, Beijing, China[J].Environmental Pollution,2014(Jan.):247-253. |
| [70] | Rhodes G;Huys G;Swings J et al.Distribution of oxytetracycline resistance plasmids between aeromonads in hospital and aquaculture environments:Implication of Tn1721 in dissemination of the tetracycline resistance determinant Tet A[J].APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2000,66(9):3883-3890. |
| [71] | Ash R J;Iverson J L.Antibiotic and disinfectant resistant bacteria in rivers of the United States[A].Minneapolis,EUA,2004 |
| [72] | Beaber J W;Hochhut B;Waldor M K .SOS response promotes horizontal dissemination of antibiotic resistance genes[J].NATURE,2003,427(6969):72-74. |
| [73] | 郭业彬,舒为群,常晓松,陈浩,杨澜,付文娟.温度与pH值对长江水系产超广谱β-内酰胺酶大肠埃希菌耐药基因转移影响分析[J].微生物学杂志,2010(05):29-35. |
| [74] | Ana Alonso;Patricia Sanchez;Jose L. Martinez .Environmental selection of antibiotic resistance genes[J].Environmental microbiology,2001(1):1-9. |
| [75] | 杨凤霞,毛大庆,罗义,汪庆,母全华.环境中抗生素抗性基因的水平传播扩散[J].应用生态学报,2013(10):2993-3002. |
| [76] | Pruden A;Pei RT;Storteboom H;Carlson KH .Antibiotic resistance genes as emerging contaminants: Studies in northern Colorado[J].Environmental Science & Technology: ES&T,2006(23):7445-7450. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%