以大肠杆菌（Escherichia coli，E．coli）为模式生物，磺胺及3种群体感应抑制剂（QSI）为研究对象，测定其单一毒性和联合毒性，采用分子对接技术初步探索了磺胺和QSI对E．coli的单一及联合毒性效应机制．结果显示，其联合毒性效应多表现为拮抗，推断可能是由于磺胺促进E．coli的SdiA蛋白的表达，后者与QSIs结合，减少其生物有效剂量，导致拮抗效应．该研究为抗生素联用及抗生素的环境联合生态风险评价提供一定的理论依据和技术支持．
Sulfonamides and three quoram sensing inhibitors ( QSIs) were chosen to study the single and mixture toxicites on E. coli. The single and mixture toxicities of sulfonamides and QSIs were determined using E. coli as a mode organism, and the mechanism of the joint effects between sulfonamides and QSIs was explored with the method of Molecular Docking. The results showed that the joint effects were mostly antagonistic. This is probably because sulfonamides could promote the expression of SdiA, with which QSIs were assumed to bind, leading to the decrease of QSIs consequently.
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