以壳聚糖、羟基磷灰石为基材制备了胆固醇/卵磷脂/壳聚糖/羟基磷灰石(Chol/PC/CS/HA)复合材料, 研究了胆固醇与卵磷脂的协同作用对壳聚糖模板中羟基磷灰石显微结构的影响。结果表明: 随着不同比例胆固醇与卵磷脂的加入, 羟基磷灰石的形貌由球状向棒状转变, 当卵磷脂与胆固醇的比例为5:1时复合材料体系中羟基磷灰石的显微形貌和尺寸与天然骨组织接近; 而没有胆固醇和卵磷脂作用的壳聚糖模板中主要以无定形的片状为主。这表明, 胆固醇和卵磷脂的存在影响了羟基磷灰石的显微结构, 有利于形成不同显微结构的羟基磷灰石。
Chitosan/hydroxyapatite composite materials were prepared, the influence of synergistic action of cholesterol and lecithin on the microscopic structure of hydroxyapatite in the chitosan substrate was investigated. The results show: for the composite materials with different proportions of cholesterol and lecithin the microscopic structure of hydroxyapatite changed from the spherical to the claviform. When the proportion of lecithin and cholesterol is 5:1, the microscopic structure and size of hydroxyapatite in composite materials is closed to nature bone tissue. But in the control system without lecithin and cholesterol, the microscopic structures of hydroxyapatite are amorphous lamellate almostly. The cholesterol and lecithin can affect the microscopic structure of hydroxyapatite. Addition the difference proportions of lecithin and cholesterol in composite materials system were benefited of formation of hydroxyapatite production of differences microscopic structure.
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