采用氧化水热法,以H2O2为氧化剂制备了磁性Fe3O4纳米颗粒.以磁性Fe3O4为核,通过反相悬浮聚合法对Fe3O4颗粒表面进行改性,在碳二亚胺的活化作用下,与壳聚糖衍生物-α-酮戊二酸缩壳聚糖(KCTS)反应制备了表面含有一定羧基的磁性Fe3O4/KCTS纳米粒子.经XRD、TEM、VSM、IR、TGA等手段对复合材料进行了表征及性能研究.结果表明,该磁性Fe3O4/KCTS纳米粒子的平均粒径为26nm,比饱和磁化强度为24.8A·m2/kg.其性能优良,具备超顺磁性,能很好的应用于生物分离,蛋白吸附等领域.
The magnetic Fe3O4/carboxyl functional chitosan composite nanoparticles have been prepared by the covalent binding of chitosan alpha-ketoglutaric acid (KCTS) onto the surface of FesO4 magnetic nanoparticles via earbodiimide activation. Transmission electron microscopy (TEM) showed that the Fe3O4/KCTS nanoparti-cles were regular sphere with a mean diameter of 26 nm. X-ray diffraction (XRD) patterns indicated that the FesO4 nanoparticles were pure FesO4 with a spinel structure, and the binding of KCTS did not result in a phase change. The binding of KCTS to the Fe3O4 nanoparticles was also demonstrated by the measurement of therrno-gravimetric analysis (TGA) and Fourier transforrm infrared (FTIR) spectra. Magnetic measurement revealed that the saturated magnetization of the Fe3O4/KCTS nanoparticles reached 24.8A · m2/kg and the nanoparticles showed the characteristics of superparamagnetism. And the nanoparticles were applied successfully to bio-sepa-rations and bio-adsorption.
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