叶酸修饰的氧化石墨烯装载阿霉素的载药性能评价

材料导报, 2014, 28(12): 59-62.

叶酸修饰的氧化石墨烯装载阿霉素的载药性能评价

张龙姣 ^1, , 张阳德 ^2, , 申玉璞 ^3, , 申玉坤 ^4,

1.中南大学肝胆肠外科研究中心,长沙410008

2.中南大学肝胆肠外科研究中心,长沙410008

3.中南大学肝胆肠外科研究中心,长沙410008

4.中南大学肝胆肠外科研究中心,长沙410008;长治医学院生物医学工程系,长治046000

基金项目: 湖南省自然科学基金(12JJ3051)

关键词：氧化石墨烯 , 叶酸 , 阿霉素 , 载药

Evaluation of Drug Loading Property of Folic Acid Modified Graphene Oxide Materials Loaded with Doxorubicine

ZHANG Longjiao ^1, , ZHANG Yangde ^2, , SHEN Yupu ^3, , SHEN Yukun ^4,

1.中南大学肝胆肠外科研究中心,长沙410008

2.中南大学肝胆肠外科研究中心,长沙410008

3.中南大学肝胆肠外科研究中心,长沙410008

4.中南大学肝胆肠外科研究中心,长沙410008;长治医学院生物医学工程系,长治046000

Keywords： graphene , oxide , folic , acid

制备了负载阿霉素的叶酸修饰的氧化石墨烯材料,并对其性能进行研究.首先制备由叶酸修饰的氧化石墨烯,记为FA/GO,然后将该复合物对药物阿霉素进行负载,记为FA/GO/DOX,通过与空白组(FA/GO)的对比分析,观察其药物负载和释放行为,选择Hela细胞作为模型进行细胞实验,考察其细胞形态、细胞毒性和生物安全性,对FA/GO/DOX载药系统的靶向性、细胞毒性和安全性能进行研究和评价,发现该材料性能良好,具有广阔的应用前景.

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材料期刊网

叶酸修饰的氧化石墨烯装载阿霉素的载药性能评价

Evaluation of Drug Loading Property of Folic Acid Modified Graphene Oxide Materials Loaded with Doxorubicine

参考文献