采用碱液置换丙二醇的方法制备物理交联壳聚糖水凝胶,研究了碱液浓度及三聚磷酸钠（TPP）离子交联预处理对凝胶结构和力学性能的影响。SEM观察结果表明水凝胶微观结构为富有纳米纤维的三维网络结构,且离子交联预处理在一定程度上会影响水凝胶内部结构的形成。无侧限压缩测试和动态力学分析（DMA）结果显示,未经离子交联的水凝胶在NaOH溶液浓度≤4mol/L时,力学性能随碱溶液浓度增大而增加,在NaOH溶液浓度为4mol/L时获得最优的力学性能;TPP交联后再经NaOH溶液处理的水凝胶其力学性能有所下降,当NaOH溶液浓度为2mol/L时可获得最优的力学性能。采用的2种物理交联方式在水凝胶形成过程中具有竞争关系。
Chitosan physical hydrogels were obtained by replacing 1,2-propanediol with alkaline solution,and the effect of the concentration of alkali and ionic crosslinked pretreatment with tripolyphosphate（TPP） on the microstructure and the mechanical properties of hydrogels was investigated.The microstructure of hydrogels showed by scanning electron microscope（SEM） was a three-dimensional network full of nano-fibers.The internal structure of the hydrogels could be affected by ionic crosslinked pretreatment.The mechanical properties characterized by unconfined compressive test and dynamic mechanical analysis showed that the mechanical properties of hydrogels without ionic-crosslinked increased with the increasing concentration of NaOH solution,the value of which was not more than 4mol/L,and the concentration of NaOH solution for the best mechanical properties was 4mol/L.The crosslinking of chitosan with TPP caused some decrease of mechanical properties of the hydrogels,and the mechanical properties of hydrogels got the best mechanical properties at 2mol/L.The two kinds of physical crosslinking methods used in this experiment had a competitive relationship.
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