磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件．本实验在模拟体液(ｓｉｍｕｌａｔｅｄ ｂｏｄｙ ｆｌｕｉｄ,ＳＢＦ)以人体骨骼肌组织内体液的正常生理流率(２ｍＬ/１００ｍＬ·ｍｉｎ)和偏离正常生理流率流动的动态条件下,研究在动态ＳＢＦ中影响致密磷酸钙陶瓷表面类骨磷灰石层形成的因素．结果表明:在生理流率条件下,材料的粗糙表面有利于类骨磷灰石的形成,加大ＳＢＦ中Ｃａ２＋、ＨＰＯ４２－离子浓度,类骨磷灰石层的形成速度加快．比起通常使用的静态浸泡试验,ＳＢＦ以生理流率流动的动态试验能够更好地模拟类骨磷灰石生长的体内环境．动态ＳＢＦ对了解类骨磷灰石形成,进而了解磷酸钙陶瓷在体内诱导成骨机理是十分有用的．
Bone-like apatite formation on the surface of calcium phosphate ceramics has been believed to be the necessary step that new bone grows on the ceramics and
to be relative to the osteoinductivity of the material. The research of the factors effecting bone-like apatite formation is a great help to understanding the mechanism
of osteoinduction. This study was a comparative study of in vitro formation of bone-like apatite on the surface of dense calcium phosphate ceramics with SBF
flowing at different speeds. The results showed that the rough surface was beneficial to the formation of bone-like apatite and the apatite formed faster in 1.5 SBF
than in SBF. Rough surface, namely, larger surface area, increased the dissolution of Ca2+, HPO42- and higher concentration of Ca2+ and HPO42- ions of SBF
was advantageous to the accumulation of Ca2+, HPO42-, PO43- near the ceramic surface. Local supersaturating concentration of Ca2+, HPO42-, PO43-
near sample surface was critical for nucleation of apatite on the surface of sample.
参考文献
| [1] | |
| [2] | Zhang X, et al. Trans. of 19th Annual Meeting of the Society for Biomaterials, Birmingham, AL, USA，1993，299. [2] Chen Weiqun, Zhang Xingdong, Weng Jie, et al. The 1st Far-Eastern Symposium on Biomedical Materials. Beijing. 1993，157--158. [3] Germine M，Parson J R. J. Biomed. Mater. Res., 1988, 22(A1): 55. [4] de Bruijn JD, Yuan H, Dekker R, { et al. in Bone Engineering, Ed. By J.E.Davies, em squared incorporated, Toronto, Canada，2000，421--431. [5] 陶祖莱. 生物流体力学，第一版. 北京: 科学出版社，1984. 1. [6] 武星户. 人体正常生理数据，第一版. 北京: 科学普及出版社，1987. 68. [7] Kokubo T, Ito S,Yamamuro T, et al. Ca, P-rich layer formed on high-strength bioactive glass- ceramic A-W. J. Biomed. Mater. Res., 1990 |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%