研究了含锶硼硅酸盐玻璃的体外生物活性和降解性.采用熔融法制备不同锶含量(SrO含量为0、2%、4%、6%、8%、10%、12%(摩尔分数))的硼硅酸盐生物玻璃粉末,粒径范围为150～300μm.将各组玻璃样品浸泡在0.02mol/L的K_2HPO_4溶液中,置于37℃恒温条件下,进行体外生物矿化反应.通过对反应样品的质量损失以及浸泡液pH值进行测定,并用XRD、FTIR以及SEM对反应过程和反应后产物进行表征.结果表明,含锶的硼硅酸盐玻璃在体外生物矿化反应中被生物降解,并转化为含锶羟基磷灰石,具有很好的生物活性和降解性;同时也观察到玻璃中引入锶元素后,在一定程度上控制玻璃的降解速度,进而控制硼的溶出速度,从一定程度上避免硼溶出速度过高可能带来的风险;ICP的结构也表明,当SrO为6%(摩尔分数),样品中硼元素溶出的速度最低.因此,用锶的含量可控制硼硅酸盐玻璃的降解速度,这种方法将在组织工程领域具有广阔的应用前景.
The bioactivity and biodegradability of the borate-based glasses containing different strontium contents (n(Sr)=0,2%,4%,6%,8%,10%,12mol%) were investigated inthis paper. The glass particles with the size of 150-300μm were prepared by a melting process, then the samples were immersed in 0.02mol/L K_2HPO_4 solution at 37℃ to research their properties of bioactivity and biodegradability. During the immersion experiment, the mass loss and pH value were measured. And the XRD and SEM were used to characterize the conversed products. The results prove that the Sr-borosilicate bioactive glasses have good biodegradability and bioactivity; in the K2HPO4 solution, they can converse to Sr-HA. SrO introduced into the borosilicate bioactive glass can change the degradation of the glass. This means the borate releasing from the glass can be controlled through the change of the strontium oxide content, therefore, the toxic of borate can be to avoided to some extent. When n(SrO)=6mol% in the composition, the degradation rate are the lowest, and the borate releasing from the glass is at the minimum. Consequently, the Sr-borosilicate bioactive glass show potential application in bone tissue engineering.
参考文献
| [1] | 宁佳,王德平,黄文旵,周萘,姚爱华,付海罗,刘欣.硼硅酸盐生物玻璃的制备及其体外生物活性和降解性[J].硅酸盐学报,2006(11):1326-1330. |
| [2] | 陈德敏,刘雪阳,钱云芳.锶磷灰石多孔陶瓷复合成骨细胞的体内异位成骨研究[J].生物医学工程与临床,2007(05):329-332,封3. |
| [3] | Capuccini C;Torricelli P;Sima F et al.[J].Acta Biomaterialia,2008,5:389-396. |
| [4] | 阚存辉;李剑农 .[J].国际口腔医学杂志,2008,35(04):34-36. |
| [5] | 冯婷,顾志鹏,任大伟,张小华,万昌秀,余喜讯.掺锶聚磷酸钙对破骨细胞的影响[J].中国组织工程研究与临床康复,2008(01):19-22. |
| [6] | 李峰,赵信义,吴军正,李焰.含锶磷酸钙骨水泥生物相容性评价[J].牙体牙髓牙周病学杂志,2006(05):264-268. |
| [7] | Huang Wenhai;Day D E;Kittiratanapiboon K.[J].Journal of Materials Science:Materials in Medicine,2006(17):583-596. |
| [8] | Hench L L;Paschall H.[J].Journal of Biomedical Material Research Symposium,1973(04):25-42. |
| [9] | 殷海荣,武丽华,陈福,安百江.Na2O-Al2O3-B2O3玻璃的热学性质和红外光谱[J].硅酸盐通报,2006(04):159-161,197. |
| [10] | 张华,胡海涛,任惠民,刘勇.硼的生理作用及其对人体健康影响的评估[J].国外医学（医学地理分册）,2001(01):9-10. |
| [11] | 黄文旵,王青,王德平.中空羟基磷灰石微球的制备工艺[J].同济大学学报（自然科学版）,2005(01):88-92. |
| [12] | Bioceramics D P.[J].Journal of Biomedical Materials Research,1987(21):219-236. |
| [13] | Yao Aihua;Wang Deping;Huang Wenhai.[J].The American Ceramic Society,2007(90):303-306. |
| [14] | Y.D.Yiannopoulos;G.D.Chryssikos;E.I.Kamitsos .Structure and properties of alkaline earth borate glasses[J].European Journal of Glass Science and Technology, PartB. Physics and Chemistry of Glasses,2001(3):164-172. |
| [15] | 贺蕴秋;王德平;徐振平.无机材料物理化学[M].北京:化学工业出版社,2005 |
| [16] | Zhao Di;Huang Wenhai;Rahaman M N et al.[J].Acta Biomaterialia,2009,5(04):1265-1273. |
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