表面改性聚乙烯亚胺-聚乙二醇/α-环糊精空心微球的制备与表征

高分子材料科学与工程, 2014, 30(8): 119-124.

表面改性聚乙烯亚胺-聚乙二醇/α-环糊精空心微球的制备与表征

张婉贞 ^1, , 程从 ^2, , 张红素 ^3, , 骆玲 ^4, , 张晟 ^5,

1.高分子材料工程国家重点实验室四川大学高分子研究所,四川成都610065

2.高分子材料工程国家重点实验室四川大学高分子研究所,四川成都610065

3.高分子材料工程国家重点实验室四川大学高分子研究所,四川成都610065

4.高分子材料工程国家重点实验室四川大学高分子研究所,四川成都610065

5.高分子材料工程国家重点实验室四川大学高分子研究所,四川成都610065

基金项目: 国家自然科学基金资助项目(50703025,51073107,21074138)

关键词：环糊精 , 主客体识别 , 自组装 , 空心微球

Preparation and Characterization of Surface-Modified Poly (Ethylenimine)-Methoxy Poly (Ethylene Glycol)/α-Cyclodextrin Hollow Microsphere

Keywords： cyclodextrin , host-guest recognition , self-assembly , hollow microspheres

首先合成了聚乙烯亚胺-聚乙二醇(PEI-b-mPEG)嵌段共聚物.然后利用α-环糊精(α-CD)与PEG和PEI之间不同的包合行为,构筑了一种以PEI为柔性链段,α-CD-PEG包合物为刚性链段的自组装空心微球PEI-b-mPEG/α-CD.最后,对PEI-b-mPEG/α-CD微球实施表面改性,得到了一种表面覆盖β-CD的空心微球.通过按磁共振、扫面电镜、透射电镜、原子力显微镜、X射线衍射和表面电位测试等方法对所得到的微球结构、性能等进行了表征.实验结果表明,这种微球还可以将喜树碱分子包合在外层β-CD内,预期在生物医学材料方面(如药物缓释和酶的固定化)会有较好的应用前景.

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