Ultrastructural Analysis on the Osteogenesis and Transformation of Calcium Phosphate Ceramics in Vivo

材料科学技术（英文）, 2004, 20(1): 59-62.

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1.Biomedical Materials and Engineering Centre, Wuhan University of Technology, Wuhan 430070, China

2.Biomedical Materials and Engineering Centre, Wuhan University of Technology, Wuhan 430070, China

3.Biomedical Materials and Engineering Centre, Wuhan University of Technology, Wuhan 430070, China

4.Biomedical Materials and Engineering Centre, Wuhan University of Technology, Wuhan 430070, China

5.Biomedical Materials and Engineering Centre, Wuhan University of Technology, Wuhan 430070, China

6.Department of Mechanical Engineering, Hong Kong University of Science and Technology, Hong Kong, China

基金项目: 国家重点基础研究发展计划(973计划)(G1999064701)

Ultrastructural Analysis on the Osteogenesis and Transformation of Calcium Phosphate Ceramics in Vivo

Keywords： Calcium phosphate ceramics

To study the osteogenesis and transformation process of calcium phosphate bioceramic in vivo, biodegradable porous β-tricalcium phosphate ceramics (β-TCP, φ5×8 mm) were implanted in the tibia of rabbits. β-TCP ceramics with surrounding bone tissue were retrieved and observed by SEM, TEM and EPMA every month after implantation.The results showed that osteogenesis was active and β-TCP ceramics bonded to bones directly. The new bones were forming and maturing as materials were continuously degrading, and materials were finally replaced by new bone. Parts of the materials were degraded, absorbed and recrystallized, while the rest were dispersed to the spongy bone and the Haversian lamella in an irregular arrangement, becoming incorporated into bone formation directly by remodeling the structure. Some β-TCP crystals cleaved along its (001) rhombohedral plane and formed lath-like crystals in vivo.

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Ultrastructural Analysis on the Osteogenesis and Transformation of Calcium Phosphate Ceramics in Vivo

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