采用磁性Fe3O4纳米颗粒为磁核,用反相悬浮聚合法制备了磁性壳聚糖复合微球,用激光粒度仪和透射电镜对磁性壳聚糖微球的尺寸和形貌进行分析,考察了壳聚糖浓度、乳化剂用量、交联剂浓度、搅拌速度等参数对壳聚糖成球的影响.结果表明:使用4 mL质量浓度为4 g·L-1壳聚糖溶液、0.1 mL司本-80和0.1 mg磁性Fe3 O4纳米颗粒,经超声分散1 h后,加入0.5 mL 4%的戊二醛,在转速350 r·min-1搅拌条件下,室温下反应2 h,可得到形貌光滑、粒径为0.5～2(u)m的磁性壳聚糖复合微球,该壳聚糖复合微球具有较好的磁响应性能.
With Fe3O4magnetic nanoparticles as magnetic nuclear, the magnetic chitosan microspheres were prepared by means of inverse suspension polymerization. The size and shape of magnetic chitosan microspheres were characterized by laser particle size analysis and TEM, respectively. The effects of the chitosan concentration, the emulsifier amount, the crosslinking reagent concentration and stirring speed on chitosan microspheres were investigated. The results show that the magnetic chitosan microspheres with smooth surface morphology and particle size in the 0. 5 - 2 μm could be prepared by using 4 mL chitosan solution of 4 g · L-1 , added 0. 1 mL Span-80 and 0. 1 mg of the Fe3O4 magnetic microsphere, which was ultrsonic dispersed for 1 h, and then added into 0. 5 mL of 4% glutaraldehyde under the stirring condition of 350 r · min-1to react for 2 h atroom temperature. The chitosan composite microspheres had better magnetic responsiveness.
参考文献
| [1] | 彭洪修,朱以华,郑志凤,古宏晨,干路平.磁性高分子微球的研究进展[J].材料导报,2001(05):46-49. |
| [2] | Emir Baki Denkbas;Ebru Kilicay;Cengiz Birlikseven .Magnetic chitosan microspheres: preparation and characterization[J].Reactive & functional polymers,2002(3):225-232. |
| [3] | 姜炜,李凤生,杨毅,刘宏英,楚建军.医用放射性核素的载体--磁性壳聚糖微球的制备[J].机械工程材料,2004(10):44-47. |
| [4] | 周利民,王一平,黄群武,刘峙嵘.Fe3O4/羧甲基化壳聚糖纳米粒子的制备与表征[C].第六届中国功能材料及其应用学术会议论文集,2007:2182-2184. |
| [5] | 胡书春,周祚万,楚珑晟.纳米PEG/Fe3 O4磁流体的制备[J].西南交通大学学报,2004(06):805-808. |
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