合成了含有少量硅氧烷基团的直链淀粉（苯基氨基甲酸酯）衍生物,通过硅氧烷基团在酸性条件下的水解、缩合,可简单、高效地实现在多孔硅胶表面的化学键合,制得键合型高效液相色谱（HPLC）手性固定相;利用1H核磁共振（1H-NMR）和红外光谱（IR）表征衍生物结构;作为填充材料（CPMs）制备的高效液相色谱柱,流动相选择范围更广,可以适用各种溶剂作为流动相,通过调整含有氯仿和四氢呋喃（不能用在传统的涂覆型手性柱中）的成分和配比,对于多种手性对映体有很好的拆分能力。
The phenylcarbamates of amylose bearing a small amount of 3-（triethoxysilyl） propyl residues were synthesized by a one-pot process and efficiently immobilized onto a silica gel through intermolecular polycondensation of the triethoxysilyl groups under acid condition.The amylose derivatives containing of the 3-（triethoxysilyl）propyl residue were efficiently immobilized with a high chiral recognition ability.The structure of the obtained chiral packing materials（CPMs） was characterized by 1H nuclear magnetic resonance（1H-NMR） and infrared spectroscopy（IR）.The immobilized CPMs can be used with the eluents containing chloroform and tetrahydrofuran,which cannot be used with the conventional coated-type CPMs.By using these eluents,the chiral recognition for many racemates is improved.
参考文献
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%