以经酸碱处理、碱热处理和阳极氧化处理后的生物活性钛材为研究对象,对材料进行了表面形貌分析和表面能的测定,并选用常见感染细菌金黄色葡萄球菌和大肠杆菌为研究菌株,采用体外共培养法培养,通过SEM对细菌的形态、在材料表面的粘附情况和粘附量进行观察,通过MTT法对细菌粘附量进行半定量测定,综合评价生物活性钛的表面结构对细菌增殖和粘附的影响. 结果表明,在3种生物活性钛材料表面,细菌的粘附和增殖受材料表面形貌影响显著,其中碱热处理钛表面和阳极氧化钛表面不利于细菌的增殖和粘附,显示出较好的抑菌性能.
参考文献
| [1] | Van Noort R .[J].Journal of Materials Science,1987,22:3801. |
| [2] | Nimomi M .[J].Advanced Materials,2003,4:445. |
| [3] | Wen HB;de-Wijn JR;Cui FZ;de-Groot K .Preparation of calcium phosphate coatings on titanium implant materials by simple chemistry.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(2):227-236. |
| [4] | Kim HM;Miyaji F;Kokubo T;Nishiguchi S;Nakamura T .Graded surface structure of bioactive titanium prepared by chemical treatment.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1999(2):100-107. |
| [5] | Yang B C;Uchida M;Kim H M et al.[J].BIOMATERIALS,2004,25:1003. |
| [6] | Feldman D S;Von Rccum A F .[J].Biomaterials,1985,6:352. |
| [7] | Gristina A G;Hobgood C D;Webb L X et al.[J].Biomaterials,1987,84:23. |
| [8] | Yea L O;Anneta R;George G et al.[J].Langmuir,1999,15:2719. |
| [9] | Gristina A G .[J].Science,1987,237:1588. |
| [10] | Dee K C;Puleo D A;Bizios R.An Introduction to Tissue-Biomaterial Interactions[M].Hoboken,New Jersey:John Wiley & Sons Inc,2002 |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%