为改善传统化学交联水凝胶的低力学性能、透明度、溶胀度和生物相容性,以无机纳米粒子硅酸镁锂(LMSH)作为物理交联剂,半乳糖氨基化的丙烯酸衍生物(GAC)作为生物相容性单体,N-异丙基丙烯酰胺(NIPAM)为功能单体,采用原位自由基聚合制备得到兼具温度敏感性和生物相容性的纳米复合水凝胶poly(NIPAM -LMSH-GAC).结果表明:LMSH在水凝胶基体中被完全剥离,并起到交联作用；相比于传统化学交联剂制备的此类水凝胶,所得物理交联的纳米复合水凝胶具有更高的溶胀度、良好的温敏性、优异的脉冲响应性,但鼠成纤细胞(L929)在纳米复合水凝胶表面的细胞数量略低；物理交联剂LMSH的使用和一定量的GAC的使用并没有明显改变水凝胶的体积相转变温度(VPTT),仍保持在33℃左右.
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