氧化镁膜AZ31B镁合金材料的细胞毒性研究

稀有金属材料与工程, 2008, 37(6): 1027-1031.

氧化镁膜AZ31B镁合金材料的细胞毒性研究

郭磊 ^1, , 刘魁 ^2, , 张世亮 ^3, , 黄晶晶 ^4, , 谭丽丽 ^5, , 杨柯 ^6,

1.中国医科大学,辽宁,沈阳,110001

2.中国医科大学,辽宁,沈阳,110001

3.中国医科大学,辽宁,沈阳,110001

4.中国科学院金属研究所,辽宁,沈阳,110016

5.中国科学院金属研究所,辽宁,沈阳,110016

6.中国科学院金属研究所,辽宁,沈阳,110016

基金项目: 国家自然科学基金(30500414) 辽宁省教育厅资助项目(05L508)

关键词：镁合金 , 氧化镁 , 成骨细胞 , 细胞毒性

Cytotoxicity of AZ31B Magnesium Alloy Covering with Magnesium Oxide

利用恒电流阳极氧化技术制备氧化镁(MgO)表面膜的AZ318镁合金材料(MgO/AZ31B),观测材料在体外生理环境中的微观形貌,评价材料的细胞毒性作用以及对体外培养的成骨细胞功能的影响.结果表明,MgO膜可有效地延缓AZ31B镁合金降解产物的释放速度,显著降低合金的致突变反应和溶血反应,对成骨细胞的增殖和成骨活性无毒性作用.在骨组织工程领域内MgO/AZ31B材料可望成为新型可降解生物医学材料.

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材料期刊网

氧化镁膜AZ31B镁合金材料的细胞毒性研究

Cytotoxicity of AZ31B Magnesium Alloy Covering with Magnesium Oxide

参考文献