通过在水溶液中复配魔芋葡甘聚糖(KGM)、黄原胶(XAN)和海藻酸钠(ALG)溶胶制备了KGM/XAN/ALG(简称K-X-A)复合凝胶.经质构、红外扫描、X射线衍射、扫描电镜、热分析对凝胶性能与结构分析表明,胃液中K-X-A间形成了较强的氢键相互作用,其复合凝胶结构致密,结晶度较高;肠液中复合凝胶仍保持网络构架,但较弱的氢键相互作用使其结构疏松.以复合凝胶为药物缓释载体,尼莫地平(NMP)和兰索拉唑(Lansoprazole)为模型药物,初步探讨了K-X-A凝胶的肠溶释药性能.
参考文献
| [1] | Jiangyang Fan;Kang Wang;Meimei Liu .In vitro evaluations of konjac glucomannan and xanthan gum mixture as the sustained release material of matrix tablet[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2008(2):241-247. |
| [2] | 缪锦灼,CHEN Qing-liang.尼莫地平壳聚糖缓释微球制备工艺及性能研究[J].中国生化药物杂志,2008(04):236-239,243. |
| [3] | 李琳琳,陈东,丁明慧,唐芳琼,孟宪伟,任俊,张琳.磁性微胶囊的制备及其药物缓控释性能[J].物理化学学报,2007(12):1969-1973. |
| [4] | Yang Jin;Hongbin Zhang;Yimei Yin;Katsuyoshi Nishinari .Comparison of curdlan and its carboxymethylated derivative by means of Rheology,DSC,and AFM[J].Carbohydrate research,2006(1):90-99. |
| [5] | Zhang H.;Nishinari K.;Williams MAK.;Foster TJ.;Norton IT.;Yoshimura M. .Gelation behaviour of konjac glucomannan with different molecular weights[J].Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies,2001(1):38-50. |
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