淀粉/PVA膜在血浆模拟液及唾液模拟液中的体外降解行为及相关体外生物相容性评价

复合材料学报, 2008, 25(6): 1-6.

淀粉/PVA膜在血浆模拟液及唾液模拟液中的体外降解行为及相关体外生物相容性评价

石锐 ^1, , 朱爱臣 ^2, , 毕经亮 ^3, , 张立群 ^4, , 陈大福 ^5, , 田伟 ^6,

1.北京化工大学,北京市新型高分子材料制备与成型加工重点实验室,北京,100029

2.北京化工大学,北京市新型高分子材料制备与成型加工重点实验室,北京,100029

3.北京化工大学,北京市新型高分子材料制备与成型加工重点实验室,北京,100029

4.北京化工大学,北京市新型高分子材料制备与成型加工重点实验室,北京,100029

5.北京市创伤骨科组织工程研究所,北京,100035

6.北京市创伤骨科组织工程研究所,北京,100035;北京积水潭医院,北京大学,第四临床医学院脊柱科,北京,100035

基金项目: 北京市自然科学基金(2061002)

关键词：淀粉 , PVA , 降解 , 生物相容性

In vitro degradation behaviour of starch/PVA films in simulated blood and simulated saliva fluid and in vitro biocompatibility evaluation

通过熔融浇注法制备出一系列厚度在0.05 mm～0.10 mm的淀粉/聚乙烯醇(PVA)(SP)薄膜.研究了薄膜在血浆(SBF)及唾液模拟液(SSF)中的降解行为,分析了降解过程中力学性能、失重率、溶胀度、热性能以及表面形态的变化.研究结果表明,膜在30天的降解过程中能够维持良好的尺寸稳定性和一定的力学强度.通过细胞毒性、细胞贴壁及溶血试验表征了膜的体外生物相容性.结果表明,SP膜具有良好的细胞和血液相容性.所有测试结果证明,SP薄膜是一种应用于诱导组织再生薄膜的潜在材料.

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