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利用细茵纤维素水凝胶膜和壳聚糖为原料,介绍了多孔复合支架的制备方法,并利用红外光谱、扫描电子显微镜、x射线衍射、元素分析及力学性能测试对多孔复合支架的特性进行了研究。结果表明,复合多孔支架的表面孔径变大、孔隙率下降,但依然呈三维网络结构;壳聚糖的加入有可能取代水分而与细菌纤维素分子链形成分子间相互作用,使细茵纤维素的链规整度下降,结晶度指数由0.82下降至0.61;力学性能有所下降,拉伸强度从140MPa下降至134MPa;这种复合多孔支架由于具有良好的生物相容性可以应用于生物医学领域,如辅料、组织工程支架等。

In this study,an novel composite porous scaffold has been successfully prepared by using bacterial cellulose gel and chitosan solution as raw materials.Properties of this bacterial cellulose/chitosan composite porous scaffold are investigated by Fourier transform infrared spectrum(FT-IR),scanning electron microscopy(SEM),X-ray diffraction(XRD),element analysis and tensile test.SEM images show that chitosan molecules are not only coated on the bacterial cellulose fibrils surface but also penetrate inside bacterial cellulose.It has very well interconnected porous network structure and large aspect surface.With introduction of chitosan,the crystal structure of bacterial cellulose becomes less regular and the crystallinity index tends to decrease from 0.82 to 0.61,which might be associated with strong interaction between bacterial cellulose and chitosan.Tensile test results indicate that tensile strength and the elongation at break tend to decrease from 140 MPa to 134 MPa and 6.7% to 4.6%,respectively.While the Young’s modulus has a slight increase from 3.65 GPa to 3.9 GPa.Since bacterial cellulose and chitosan both have good biocompatibility,this composite porous scaffold might have potential biomedical applications such as tissue engineering scaffold,would dressing material,etc.

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