通过直接酰胺化反应,用氨基封端聚乙二醇(H2N-PEG-NH2)对马来酸酐改性聚乳酸(MPLA)进行了本体改性.用红外、核磁和差示扫描技术对改性材料进行了表征,用FITC荧光标记牛血清白蛋白(FITC-BSA)对材料的非特异性吸附进行了检测.结果表明,聚乙二醇被成功地接枝到MPLA上,与聚乳酸(PLA)和MPLA相比,得到的产物(PPLA)明显降低了对牛血清白蛋白的非特异性吸附,仅为PLA的37.3%.
参考文献
| [1] | Zhang X C;McAuley K B;Gossen M F A .[J].Journal of Controlled Release,1995,34(02):175. |
| [2] | Cao X;Schoichet MS .Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders.[J].Biomaterials,1999(4):329-339. |
| [3] | Landry F B;Bazile D V;Spenlehauer G et al.[J].STP PHARMA SCIENCES,1996,6(03):195－202. |
| [4] | Gref R;Luck M;Quellec P et al.[J].Colloids and Surfaces B-Biointerfaces,2000,18:301－313. |
| [5] | Deng X;Zhou S;Li X et al.[J].Journal of Controlled Release,2001,71:165. |
| [6] | Li X;Zhang Y;Yan R et al.[J].Journal of Controlled Release,2000,68:41－52. |
| [7] | Jiang W;Schwendeman SP .Stabilization and controlled release of bovine serum albumin encapsulated in poly(D, L-lactide) and poly(ethylene glycol) microsphere blends.[J].Pharmaceutical research,2001(6):878-885. |
| [8] | Tobio M;Sanchez A;Vila A et al.[J].Colloids Surg B Biointerfaces,2000,18:315－323. |
| [9] | 曹雪波 .马来酸酐改性聚乳酸的研究[D].重庆大学,2001. |
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