以外消旋乳酸(D,L-LA)和不同数均分子量(M_n)的聚乙二醇(PEG)为原料,通过熔融缩聚法,合成了系列聚乳酸聚乙二醇(PLEG).最佳工艺条件为:以(Sn(Oct)_2)为催化剂,m(Sn(Oct)_2)为0.8%,n(PEG):n(D,L-LA)=1:600,聚合温度170℃,压力0.096MPa条件下,反应8h.用特性粘度测试、FT-IR、XRD、接触角等对其进行表征,实验结果表明系列PLEG中PLEG-800接触角为63°,表明其亲水性能最好;PEG-800和乳酸共聚合成的PLEG的粘均分子量最大,可达48997,与PDLLA相比,结晶度有较大提高,亲水性得到改善.
The biodegradable material poly(D,L-lactic acid)-polyethylene glycol(PLEG) was synthesized with stannous octanoate as catalyst via directly melt polycondensation of D,L-racemic lactic acid (D,L-LA) as monomer with PEG-400,600,800,1000 and 2000 at molar ratio n(PEG)/n(D,L-LA)=1/600.The copolymerization reaction was performed at temperature of 170℃,m(Sn(Oct)_2) of 0.8%,and pressure of 0.096MPa for 8h.The PLEGs were characterized by viscosity-average molecular weight,FT-IR,XRD and contact angle testing.The results demonstrate that the contact angle of PLEG-800 was 63°and the maximum M_η of PLEG-800 can reach 48997.Better hydrophilicity and crystallinity can be reached in case of PEG is chosen as 800,compared with poly(D,L-lactic acid).
参考文献
| [1] | Ruan G;Feng SS .Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel.[J].Biomaterials,2003(27):5037-5044. |
| [2] | Miura H;Onishi H;Sasatsu M;Machida Y .Antitumor characteristics of methoxypolyethylene glycol-poly(DL-lactic acid) nanoparticles containing camptothecin[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(1):101-113. |
| [3] | 王方,汪朝阳,赵耀明.聚乙二醇改性聚乳酸类材料的合成及应用[J].合成树脂及塑料,2003(06):58-61. |
| [4] | Jain, AK;Goyal, AK;Gupta, PN;Khatri, K;Mishra, N;Mehta, A;Mangal, S;Vyas, SP .Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2009(2):161-169. |
| [5] | Sheng Y;Yuan Y;Liu C S et al.[J].Journal of Materials Science:Materials in Medicine,2009,39(11):3853-3855. |
| [6] | Kang Moo Huh;You Han Bae .Synthesis and characterization of poly(ethylene glycol)/poly(L-lactic acid) alternating multiblock copolymers[J].Polymer: The International Journal for the Science and Technology of Polymers,1999(22):6147-6155. |
| [7] | 汪朝阳,王方,赵耀明,周玲.熔融聚合法直接合成生物降解材料PLEG[J].功能高分子学报,2004(01):30-34. |
| [8] | 宋谋道,朱吉亮,张邦华,郝广杰,张莹,赵英奇,范玉玲,杨世强.可生物降解的聚乳酸弹性体的性能研究[J].高分子学报,1998(04):0. |
| [9] | 樊国栋,杨海燕,王海花,陈佑宁.聚乳酸均聚物的IPDI/PEG二步法扩链改性研究[J].现代化工,2008(11):52-54. |
| [10] | 林尚安;陆耘;梁兆熙.高分子化学[M].北京:科学出版社,1982:265-270. |
| [11] | 邓芹英;刘岚;邓慧敏.波谱分析教程[M].北京:科学出版社,2003:44-58. |
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