Adaptation of a Biomineralization Strategy for Remineralization of Enamel and Dentin

武汉理工大学学报-材料科学版(英文版), 2005, 20(z1): 60-62.

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1.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

2.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

3.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

4.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

5.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

6.Department of Dental Materials,West China College of Stomatology,Sichuan University,Chengdu 610041,China

基金项目: 国家高技术研究发展计划(863计划)(2002AA3260806)

Adaptation of a Biomineralization Strategy for Remineralization of Enamel and Dentin

Keywords： biomimetic

The bio- inspired strategy of triggered release of Ca2 +, Pi, F from prosomal compartments was used to induce rapid formation of FHA for potential dental use: Calcium and inorganic phosphate salts were separately loaded into temperature-sensitive liposome composed of 90% DPPC and 10% DMPC. When heated from the room temperature to 35- 37 ℃ , the entrapped calcium, inorganic phosphate and fluorin released from the liposome. A mixture of Ca- Pi and F-loaded liposome formed apatite. The mineral was indicated by a rapid drop in suspension PH from 7.4 approximately 6. This was illustrated by applying a liposome suspension warmed human dentin and enamel surface which resulted in deposition of apatite onto the tissue substrates.

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Adaptation of a Biomineralization Strategy for Remineralization of Enamel and Dentin

参考文献