介绍了静电喷射制备微球、微粒的原理、装置及所用聚合物.总结了静电喷射制备微球、微粒的影响因素及所制备微球、微粒的用途.静电喷射制备微球、微粒的影响因素主要包括电压、聚合物溶液流量、聚合物溶液浓度及电导率.已通过静电喷射制备微球、微粒的聚合物有聚己内酯、聚乳酸、聚丙交酯乙交酯、聚膦腈、聚乙烯基吡咯烷酮、壳聚糖等,主要用于药物、蛋白质、酶等生物活性分子的包埋研究.
参考文献
| [1] | 陈国广,任皓,李学明,赵刚,韦萍.聚乳酸羟基乙酸载药微球的研究进展[J].华西药学杂志,2006(02):181-183. |
| [2] | 付寒,温新国,典灵辉,潘昕,吴传斌.粒径均一单分散载药微球的制备技术及其应用[J].中国医药工业杂志,2011(11):856-862,870. |
| [3] | Berkland C;Kim KK .Controlling surface nano-structure using flow-limited field-injection electrostatic spraying (FFESS) of poly(d,l-lactide-co-glycolide).[J].Biomaterials,2004(25):5649-5658. |
| [4] | Martwiset, S.;Jaroensuk, K. .Electrospinning of poly(vinyl alcohol) and poly(4-styrenesulfonic acid) for fuel cell applications[J].Journal of Applied Polymer Science,2012(3):2594-2600. |
| [5] | Agarwal, P.;Mishra, P.K.;Srivastava, P. .Statistical optimization of the electrospinning process for chitosan/polylactide nanofabrication using response surface methodology[J].Journal of Materials Science,2012(10):4262-4269. |
| [6] | Yuan, J.;Mo, H.;Wang, M.;Li, L.;Zhang, J.;Shen, J. .Reactive electrospinning of poly(vinyl alcohol) nanofibers[J].Journal of Applied Polymer Science,2012(2):1067-1073. |
| [7] | Liu, W.;Wang, S.;Xiao, M.;Han, D.;Meng, Y. .A proton exchange membrane fabricated from a chemically heterogeneous nonwoven with sandwich structure by the program-controlled co-electrospinning process[J].Chemical communications,2012(28):3415-3417. |
| [8] | Michal Dubsky;Sarka Kubinova;Jakub Sire;Ludek Voska;Robert Zajicek;Alena Zajicova;Petr Lesny;Alexandra Jirkovska;Jiff Michalek;Marcela Munzarova;Vladimir Holan;Eva Sykova .Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing[J].Journal of Materials Science. Materials in Medicine,2012(4):931-941. |
| [9] | Ding L;Lee T;Wang CH .Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(2):395-413. |
| [10] | Xie JW;Ng WJ;Lee LY;Wang CH .Encapsulation of protein drugs in biodegradable microparticles by co-axial electrospray[J].Journal of Colloid and Interface Science,2008(2):469-476. |
| [11] | Yeo LY;Gagnon Z;Chang HC .AC electrospray biomaterials synthesis[J].Biomaterials,2005(31):6122-6128. |
| [12] | Reyderman L;Stavchansky S .Electrostatic spraying and its use in drug delivery-cholesterol microspheres[J].International Journal of Pharmaceutics,1995,124:75. |
| [13] | Xie J;Marijnissen JC;Wang CH .Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro.[J].Biomaterials,2006(17):3321-3332. |
| [14] | Bai J;Li YX;Li MY;Gao JL;Zhang XM;Wang SG;Zhang CQ;Yang QB .A novel approach to prepare AgCl/PVP nanocomposite microspheres via electrospinning with sol-gel method[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2008(1/3):259-262. |
| [15] | Zhang S;Kawakami K .One-step preparation of chitosan solid nanoparticles by electrospray deposition.[J].International Journal of Pharmaceutics,2010(1/2):211-217. |
| [16] | Ranganath SH;Kee I;Krantz WB;Chow PK;Wang CH .Hydrogel matrix entrapping PLGA-paclitaxel microspheres: drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy.[J].Pharmaceutical research,2009(9):2101-2114. |
| [17] | Xie J;Tan RS;Wang CH .Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma in vitro.[J].Journal of biomedical materials research, Part A,2008(4):897-908. |
| [18] | Almería, B.;Fahmy, T.M.;Gomez, A. .A multiplexed electrospray process for single-step synthesis of stabilized polymer particles for drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2011(2):203-210. |
| [19] | Ye, M.;Kim, S.;Park, K. .Issues in long-term protein delivery using biodegradable microparticles[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(2):241-260. |
| [20] | Youliang Hong;Yanyan Li;Yizi Yin .Electrohydrodynamic atomization of quasi-monodisperse drug-loaded spherical/wrinkled microparticles[J].Journal of Aerosol Science,2008(6):525-536. |
| [21] | Yu F K;Maruyama T;Iwamatsu Y et al.Preparation of monodispersed polyelectrolyte microcapsules with high encapsulation efficiency by an electrosray technique[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2010,370(1-3):28. |
| [22] | 周圆圆,薛立伟,毛吉富,蔡晴,金日光.静电喷雾法制备聚膦腈微球[J].高分子学报,2010(01):125-130. |
| [23] | Chang SJ;Kuo SM;Manousakas I .Preparation and characterization of hyaluronan/collagen II microspheres under an electrostatic field system with disc electrodes.[J].Acta biomaterialia,2009(1):101-114. |
| [24] | Li X R;MacEwan M R et al.Fabrication of density gradients of biodegradable polymer microparticles and their use in guiding neurite outgrowth[J].Advanced Functional Materials,2010,20(10):1632. |
| [25] | Zhang X;Zhao Y .Programmable patterning of polymeric microparticles by floating electrodes-assisted electrosray[J].Journal of Micromechanics and Microengineering,2012,22(04):047001. |
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