采用超临界CO_2辅助膨胀结合喷嘴雾化分散过程,制备可用于药物缓控释制剂材料聚己酸内酯微细颗粒.实验考察了聚己酸内酯-二氯己烷溶液浓度、流量、预膨胀温度、预膨胀压力对颗粒尺寸和形貌的影响.结果表明,增加预膨胀压力、降低预膨胀温度、减小喷嘴孔径能得到聚已内酯微细颗粒;在一定的溶液初始浓度、溶液流率范围内,较高的溶液初始浓度、较高的溶液流率,可得到小于1 μm聚已酸内酯微细球状颗粒.
Polycaprolactone(PCL)is a polymeric material that is used in controlled release medicine or as a drug carrier, and the microparticle formation of PCL is studied using supercritical carbon dioxide assisted expansion technology with a custom-made special nozzle. The influences of concentration of PCL- dichloromethane solution,molar flux, and the pre-expansion temperature and pressure were discussed. Scanning electronic microscope(SEM)photos show that mean particle size(MPS)of PCL produced by supercritical carbon dioxide assisted expansion is less than 1 μm, which can be obtained within certain concentration and molar flux of PCL. And higher pre-expansion pressure, lower pre-expansion temperature, smaller the diameter of nozzle are favorable for narrow particles size distribution.
参考文献
| [1] | 张娜,郭圣荣.聚己酸内酯及其在医药领域的应用[J].生物医学工程学杂志,2003(04):746-749. |
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