以克拉霉素为模型药物,采用乳化-溶剂挥发法制备乙基纤维素载药微球(EM),并通过内部凝胶化法进行包衣制得海藻酸钠-乙基纤维素载药微囊(AEM),最后通过离子交联法进一步包衣制得壳聚糖-海藻酸钠-乙基纤维素微囊(CAEM).考察了制备条件对微囊中药物包封率及载药量的影响,并进一步评价了微囊的体外释放及漂浮性能.结果表明,EM及CAEM球形度均较好,药物包封率分别为80.9%～97.3%及72.3%～78.2%;载药量分别为16.2%～49.8%及7.1%～12.7%.CAEM在pH为5的醋酸缓冲液中,6h的累积释放率为56.6%～76.9%,漂浮率＞70%,具有较好的缓释效果及良好的体外漂浮性能.CAEM有望延长药物在胃内的滞留时间,提高胃粘膜药物浓度,从而提高幽门螺旋杆菌的根除率.
参考文献
| [1] | Francesco P;Asghar Q;Lea M et al.[J].HELICOBACTER,2003,8:53-60. |
| [2] | Keshavarz AA;Rahimi A .[J].Irish Journal of Medical Science,2004,29:40-42. |
| [3] | Malfertheiner P;Megraud F;Oorain C et al.[J].Alimentary Pharmacology and Therapeutics,2002,16:167-180. |
| [4] | Murata Y;Kofuji K;Kawashima S .[J].Journal of Biomaterials Science-Polymer Edition,2003,14:581-588. |
| [5] | Wang J;Tauchi Y;Deguchi Y et al.[J].Drug Delivery,2000,7:237-243. |
| [6] | Hejazi R;Amiji M .Stomach-specific anti-H. pylori therapy. I: Preparation and characterization of tetracyline-loaded chitosan microspheres.[J].International Journal of Pharmaceutics,2002(1/2):87-94. |
| [7] | Umamaheswari RB;Jain S;Tripathi PK;Agrawal GP;Jain NK .Floating-bioadhesive microspheres containing acetohydroxamic acid for clearance of Helicobacter pylori.[J].Drug delivery,2002(4):223-231. |
| [8] | 中国药典[S].北京:化学工业出版社,2000. |
| [9] | Umamaheswari R B;Jain S;Jain N K .[J].Drug Delivery,2003,10:151-160. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%