光敏剂产生单线态氧的能力是评价其光动力活性的因素之一。采用2,5-二甲基呋喃为吸收剂,通过高效液相色谱法研究了1-3代硝基芳基苄醚树枝配体轴向取代酞菁硅（Ⅳ）单线态氧的生成速率、生成速率常数及量子产率。结果表明,轴向取代酞菁硅（Ⅳ）单线态氧的生成速率和生成速率常数均随着树枝代数的增加而逐渐增大,低代的树枝配体轴向取代酞菁硅（Ⅳ）的单线态氧量子产率较高,这可能与不同代树枝配体对酞菁核的位点分离有关。研究将为开发轴向取代酞菁硅（Ⅳ）配合物作为新型光敏剂提供重要的理论参考。
The singlet oxygen(102) production capabilitity of photosensitizers is an important factor to assess their potential as effective photodynamic therapy(PDT) agents. In this paper, the 102 production rate, produc- tion rate constant and quantum yield of silicon(IV) phthalocyanine axially bearing 1-3rd generations poly(nitro aryl benzyl ether) dendritic substituents were evaluated by a high performance liquid chromatographic method. The results show that the 1O2 production rate and production rate constant of these compounds increase gradu- ally with dendritic generations increase. And the 102 quantum yield of silicon(IV) phthalocyanine with 1St gen- eration dendritic ligand was the highest. This may be due to the isolation effect of the dendritic ligands on the phthalocyanine core. The parameters of the observed 102 production properties will provide valuable data for these dendrimer phthalocyanines as promising photosensitizer in PDT application.
参考文献
| [1] | Serra A;Pineiro M;Pereira N et al.A look at clinicalapplications and developments of photodynamic therapy[J].Oncology Reviews,2008,2(04):235-249. |
| [2] | Asta Juzeniene;Johan Moan .The history of PDT in Norway Part one: Identification of basic mechanisms of general PDT[J].Photodiagnosis and photodynamics therapy,2007(1):3-11. |
| [3] | Ochsner M .Light scattering of human skin:a compari-son between zinc(H)-phthalocyanine and photofrin Q[J].Journal of Photochemistry and Photobiology B:Biology,1996,32(1-2):3-9. |
| [4] | 阙寿林,彭亦如,张宏,陈莉莉,黄丽珊,刘建生,陈奎治,吴松一.负载芳基苄醚树枝形酞菁锌聚合物纳米粒子的合成及其离体光动力活性[J].化学学报,2011(06):731-738. |
| [5] | 陈莉莉,彭亦如,林萍萍,阙寿林,黄丽珊,陈奎治,徐国兴.负载空间链四（6-氨基己酸磺酰基）铝氯酞菁聚合物纳米粒子的合成及其离体光动力活性[J].无机化学学报,2011(02):327-332. |
| [6] | Matthew Brewis;Madeline Helliwell;Neil B.McKeown;Stephen Reynolds;Andrew Shawcross .Phthalocyanine-centred aryl ether dendrimers with oligo(ethyleneoxy)surface groups[J].Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry,2001(5):813-816. |
| [7] | Yang Qin;Yang Yongli;Wang Wendong et al.Studyon(3-cyclodextrin and metal phthalocyanine effects offunctional assembly[J].Journal of Functional Materials,2011,42(07):1293-1296. |
| [8] | Masakazu N;Hiroaki H;Atsuya M et al.Singlet molecularoxygen generation by watei^soluble phthalocyanine dendrim-ers with different aggregation behavior[J].Journal of Por-phyrins and Phthalocyanines,2011,15(01):47-53. |
| [9] | Masakaz N;Atsuya M;Yoshihiro S et al.Synthesis andphotophysical properties of water-soluble dendrimersbearing a phthalocyanine core[J].Journal of Porphyrinsand Phthalocyanines,2007,11(06):448-454. |
| [10] | Yiru Peng;Pingping Lin;Jinhuo Lin;Guoxing Xu;Hong Zhang;Jicheng Shi .Cationic Triblock Copolymer Micelles Deliver Anionic Spacer Chains Substituted Aluminum Phthalocyanine For Enhancement Intracellular Photodynamic Efficacy[J].Materials Letters,2009(11):914-916. |
| [11] | John W.Snyder;Esben Skovsen;John D.C.Lambert;Peter R.Ogilby .Subcellular,Time-Resolved Studies of Singlet Oxygen in Single Cells[J].Journal of the American Chemical Society,2005(42):14558-14559. |
| [12] | Lavi A;Weitman H;Holmes RT;Smith KM;Ehrenberg B .The Depth of Porphyrin in a Membrane and the Membrane's Physical Properties Affect the Photosensitizing Efficiency.[J].Biophysical Journal,2002(4):2101-2110. |
| [13] | Ogunsipe A.;Maree D.;Nyokong T. .Solvent effects on the photochemical and fluorescence properties of zinc phthalocyanine derivatives[J].Journal of Molecular Structure,2003(1/3):131-140. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%