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为了获得具有较高生物活性和良好生物矿化性能的生物活性材料,以正硅酸乙酯(TEOS)及磷酸三乙酯(TEP)为前驱体,硝酸钙(CN)为添加剂,盐酸为催化剂,在不同水与醇盐物质的量比(R)条件下,采用溶胶-凝胶法制备了CaO-P2O5-SiO2系统生物活性玻璃.利用生物活性材料的体外评价方法及FTIR、XRD、SEM测试技术对样品的结构和生物活性进行了分析研究.结果表明:经模拟体液(SBF)浸泡后, 随着水解度的增大,其表面羟基磷灰石层的形成能力逐渐减弱.

参考文献

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[2] Priya Saravanapavan;Larry L. Hench .Low-temperature synthesis, structure, and bioactivity of gel-derived glasses in the binary CaO-SiO_2 system[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(4):608-618.
[3] 陈良,徐玲玲.SiO2-CaO-P2O5体系生物活性材料的制备研究[J].硅酸盐通报,2009(04):686-691.
[4] Levy S;Van Dalen M;Agonafer S;Soboyejo WO .Cell/surface interactions and adhesion on bioactive glass 45S5[J].Journal of Materials Science. Materials in Medicine,2007(1):89-102.
[5] Jung-Young Choi;Hae-Hyoung Lee;Hae-Won Kim .Bioactive sol-gel glass added ionomer cement for the regeneration of tooth structure[J].Journal of Materials Science. Materials in Medicine,2008(10):3287-3294.
[6] Izquierdo Barba-I;Salinas AJ;Vallet RegI-M .Effect of the continuous solution exchange on the in vitro reactivity of a CaO-SiO(2) sol-gel glass.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2000(2):191-199.
[7] 黄剑锋.溶胶-凝胶原理与技术[M].北京:化学工业出版社,2005:58-65.
[8] Huang WH;Day DE;Kittiratanapiboon K;Rahaman MN .Kinetics and mechanisms of the conversion of silicate (45S5), borate, and borosilicate glasses to hydroxyapatite in dilute phosphate solutions[J].Journal of Materials Science. Materials in Medicine,2006(7):583-596.
[9] 陈晓峰,郭常亮,赵娜如,谢林.溶胶-凝胶生物活性玻璃超细粉体的制备与生物矿化性能研究[J].无机材料学报,2008(05):1027-1032.
[10] Aili Wang;Hengbo Yin;Dong Liu;Huixiong Wu;Min Ren;Tingshun Jiang;Xiaonong Cheng;Yiqing Xu .Size-controlled synthesis of hydroxyapatite nanorods in the presence of organic modifiers[J].Materials Letters,2007(10):2084-2088.
[11] 陈晓峰,李玉莉,赵娜如.溶胶-凝胶生物活性玻璃的纳米结构分析研究[J].硅酸盐通报,2007(02):247-251.
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