以聚乳酸(PLA)和骨粉为原料,利用超声波分散技术,采用溶液共混法制备PLA/骨粉杂化材料.通过FT-IR,DSC,SEM等测试手段对相关产物进行表征.结果显示,骨粉在PLA基质中分散均匀,与PLA基质间以氢键结合,相容性良好.与PLA相比,PLA/骨粉的耐温性能明显提高.杂化材料在37℃的生理盐水中的降解试验结果表明,PLA/骨粉杂化材料降解12周后,呈三维立体支架结构,利于血管及骨细胞黏附长入.此外,由于骨粉的引入,使PLA降解的酸性产物在一定的程度上得到中和,可以减小因PLA酸性过高引发的炎症反应,便于细胞增殖和组织修复.
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