纳米金具有独特的理化性能,在肿瘤诊断和治疗中取得了许多重要进展.综述了纳米金的结构组成、粒径尺寸、形貌特征对其本身性能的影响,介绍了纳米金对肿瘤标志物的检测和作为造影剂对肿瘤成像的研究进展,着重评述了纳米金应用于体内外肿瘤光学成像方面的研究情况,展望了其未来的发展前景.
参考文献
[1] | Tapan K.Sau;Catherine J.Murphy .Room Temperature,High-Yield Synthesis of Multiple Shapes of Gold Nanoparticles in Aqueous Solution[J].Journal of the American Chemical Society,2004(28):8648-8649. |
[2] | Frens G .Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions[J].Nature,1973,241(105):20. |
[3] | 卜扬,杨清,孟琦,胡赢,黄杉生.空壳纳米金修饰的新型DNA传感器[J].化学学报,2010(07):672-678. |
[4] | Adam M. Schwartzberg;Tammy Y. Oshiro;Jin Z. Zhang;Thomas Huser;Chad E. Talley .Improving Nanoprobes Using Surface-Enhanced Raman Scattering from 30-nm Hollow Gold Particles[J].Analytical chemistry,2006(13):4732-4736. |
[5] | Sun Y G;Mayers B;Xia Y N .Metal nanostructures with hollow interiors[J].Advanced Materials,2003,15(7-8):641. |
[6] | 李建平,高会玲,熊志刚.磁性纳米金共价固定癌胚抗原单克隆抗体的电流型免疫传感器[J].高等学校化学学报,2008(11):2149-2154. |
[7] | Park HY;Schadt MJ;Wang L;Lim IIS;Njoki PN;Kim SH;Jang MY;Luo J;Zhong CJ .Fabrication of magnetic core @ shell Fe oxide @ Au nanoparticles for interfacial bioactivity and bio-separation[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(17):9050-9056. |
[8] | Linlin Sun;Jine Wang;Zhenxin Wang .Recognition and transmembrane delivery of bioconjugated Fe2O3@Au nanoparticles with living cells[J].Nanoscale,2010(2):269-276. |
[9] | Mishra YK;Mohapatra S;Avasthi DK;Kabiraj D;Lalla NP;Pivin JC;Sharma H;Kar R;Singh N .Gold-silica nanocomposites for the detection of human ovarian cancer cells: a preliminary study[J].Nanotechnology,2007(34):45606-1-45606-5-0. |
[10] | Hu K W;Jhang F Y;Su C H et al.Fabrication of Gd2O(CO3)2 @ H2O/silica/gold hybrid particles as a bifunctional agent for MR imaging and photothermal destruction of cancer cells[J].Journal of Materials Chemistry,2009,19(15):2147. |
[11] | Ji XJ;Shao RP;Elliott AM;Stafford RJ;Esparza-Coss E;Bankson JA;Liang G;Luo ZP;Park K;Markert JT .Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2007(17):6245-6251. |
[12] | Malugin A;Ghandehari H .Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres.[J].Journal of applied toxicology,2010(3):212-217. |
[13] | Yu Y Y;Chang S S;Lee C L et al.Gold nanorods:Elec trochemical synthesis and optical properties[J].Journal of Physical Chemistry B,1997,101(34):6661. |
[14] | Nikoobakht B.;El-Sayed MA. .Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method[J].Chemistry of Materials,2003(10):1957-1962. |
[15] | Zhu, J.;Yong, K.-T.;Roy, I.;Hu, R.;Ding, H.;Zhao, L.;Swihart, M.T.;He, G.S.;Cui, Y.;Prasad, P.N. .Additive controlled synthesis of gold nanorods (GNRs) for two-photon luminescence imaging of cancer cells[J].Nanotechnology,2010(28):285106-1-285106-8. |
[16] | Kopwitthaya, A.;Yong, K.-T.;Hu, R.;Roy, I.;Ding, H.;Vathy, L.A.;Bergey, E.J.;Prasad, P.N. .Biocompatible PEGylated gold nanorods as colored contrast agents for targeted in vivo cancer applications[J].Nanotechnology,2010(31):315101-1-315101-10. |
[17] | Chen L L;Jiang L;Wang Y L et al.Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging[J].J Zhejiang Univ Sci B (Biomed Biotechn),2010,11(06):417. |
[18] | Jingyi Chen;Fusayo Saeki;Benjamin J.Wiley;Hu Cang;Michael J.Cobb;Zhi-Yuan Li;Leslie Au;Hui Zhang;Michael B.Kimmey;Xingde Li;Younan Xia .Gold Nanocages:Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents[J].Nano letters,2005(3):473-478. |
[19] | Au L;Zheng D S;Zhou F et al.A quantitative study on the photothermal effect of immnuno gold nanocages targeted to breast cancer cells[J].ACS Nano,2008,2(08):1645. |
[20] | Chen, J.;Glaus, C.;Laforest, R.;Zhang, Q.;Yang, M.;Gidding, M.;Welch, M.J.;Xia, Y. .Gold nanocages as photothermal transducers for cancer treatment[J].Small,2010(7):811-817. |
[21] | Wu, X.;Ming, T.;Wang, X.;Wang, P.;Wang, J.;Chen, J. .High-photoluminescence-yield gold nanocubes: For cell imaging and photothermal therapy[J].ACS nano,2010(1):113-120. |
[22] | Kondo Y;Takayanagi K .Synthesis and characterization of helical multi-shell gold nanowires[J].Science,2000,289(5479):606. |
[23] | 谢微,苏乐,沈爱国,胡继明.金纳米花生的制备及其SERS增强研究[J].分析化学,2009(z1):342. |
[24] | Ge, Y.;Fa, W.;Zhou, J.;Dong, J. .Single-walled gold nanotubes grown in carbon nanotubes: Molecular dynamics simulations[J].Physics Letters, A,2010(31/32):3258-3262. |
[25] | 张浩然,满石清,徐萌,朱新海.金核壳纳米粒子的控制合成及其生物复合[J].无机化学学报,2010(10):1768-1775. |
[26] | Tapan K. Sau;Andrey L. Rogach .Nonspherical Noble Metal Nanoparticles: Colloid-Chemical Synthesis and Morphology Control[J].Advanced Materials,2010(16):1781-1804. |
[27] | 肖桂娜,满石清.帽状金纳米结构的制备、表征及表面增强拉曼散射活性[J].高等学校化学学报,2009(05):849-854. |
[28] | Chithrani BD;Ghazani AA;Chan WCW .Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells[J].Nano letters,2006(4):662-668. |
[29] | Zhang G;Yang Z;Lu W;Zhang R;Huang Q;Tian M;Li L;Liang D;Li C .Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice.[J].Biomaterials,2009(10):1928-1936. |
[30] | Gold nanoparticle probes[J].Coordination chemistry reviews,2009(11/12):1607-1618. |
[31] | Kang, JH;Asami, Y;Murata, M;Kitazaki, H;Sadanaga, N;Tokunaga, E;Shiotani, S;Okada, S;Maehara, Y;Niidome, T;Hashizume, M;Mori, T;Katayama, Y .Gold nanoparticle-based colorimetric assay for cancer diagnosis[J].Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices,2010(8):1869-1874. |
[32] | Jing-Jing Zhang;Fang-Fang Cheng;Ting-Ting Zheng;Jun-Jie Zhu .Design and Implementation of Electrochemical Cytosensor for Evaluation of Cell Surface Carbohydrate and Glycoprotein[J].Analytical chemistry,2010(9):3547-3555. |
[33] | Jiang, W.;Yuan, R.;Chai, Y.-Q.;Yin, B. .Amperometric immunosensor based on multiwalled carbon nanotubes/Prussian blue/nanogold-modified electrode for determination of α-fetoprotein[J].Analytical Biochemistry: An International Journal of Analytical and Preparative Methods,2010(1):65-71. |
[34] | Zhuo Y;Yuan R;Chai YQ;Tang DP;Zhang Y;Wang N;Li XL;Zhu Q .A reagentless amperometric immunosensor based on gold nanoparticles/thionine/Nafion-membrane-modified gold electrode for determination of alpha-1-fetoprotein[J].Electrochemistry communications,2005(4):355-360. |
[35] | Dianping Tang;Ruo Yuan;Yaqin Chai .Electrochemical immuno-bioanalysis for carcinoma antigen 125 based on thionine and gold nanoparticles-modified carbon paste interface[J].Analytica chimica acta,2006(2):158-165. |
[36] | Chen S H;Yuan R;Chai Y Q et al.Electrochemical sensing platform based on tris,(2,2-bipyridyl)cobalt(Ⅲ) and multiwall carbon nanotubes-Nafion composite for immunoassay of carcinoma antigen-125[J].Electrochimica Acta,2009,54(28):7242. |
[37] | Du D;Xu XX;Wang SF;Zhang AD .Reagentless amperometric carbohydrate antigen 19-9 immunosensor based on direct electrochemistry of immobilized horseradish peroxidase[J].Talanta: The International Journal of Pure and Applied Analytical Chemistry,2007(3):1257-1262. |
[38] | Kim, D.-J.;Lee, N.-E.;Park, J.-S.;Park, I.-J.;Kim, J.-G.;Cho, H.J. .Organic electrochemical transistor based immunosensor for prostate specific antigen (PSA) detection using gold nanoparticles for signal amplification[J].Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices,2010(11):2477-2482. |
[39] | PRASHANT K. JAIN;XIAOHUA HUANG;IVAN H. EL-SAYED .Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine[J].Accounts of Chemical Research,2008(12):1578-1586. |
[40] | Krug J T;Wang G D;Emory S R et al.Efficient Raman enhancement and intermittent light emission observed in single gold nanocrystals[J].Journal of the American Chemical Society,1999,121(39):9208. |
[41] | Jain PK;El-Sayed MA .Universal scaling of plasmon coupling in metal nanostructures: Extension from particle pairs to nanoshells[J].Nano letters,2007(9):2854-2858. |
[42] | Xiaohua Huang;Ivan H.El-Sayed;Wei Qian;Mostafa A.El-Sayed .Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods[J].Journal of the American Chemical Society,2006(6):2115-2120. |
[43] | Lee, S;Chon, H;Lee, M;Choo, J;Shin, SY;Lee, YH;Rhyu, IJ;Son, SW;Oh, CH .Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres[J].Biosensors & Bioelectronics,2009(7):2260-2263. |
[44] | Qian,X;Peng,XH;Ansari,DO;Yin-Goen,Q;Chen,GZ;Shin,DM;Yang,L;Young,AN;Wang,MD;Nie,S .In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags.[J].Nature biotechnology,2008(1):83-90. |
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