通过原位聚合法制备了可注射纳米羟基磷灰石/天门冬氨酸-谷氨酸共聚物/硫酸钙复合材料( HA/PAG/CS),采用FTIR、XRD、SEM对复合材料的组成结构、表面形貌及力学性能进行了表征,研究了复合材料在模拟体液(SBF)中的降解性能.结果显示:复合材料无机相羟基磷灰石、硫酸钙与有机相天门冬氨酸-谷氨酸共聚物之间存在化学相互作用,具有良好的抗压强度；7周后,复合材料在SBF中完全降解,降解方式为表面降解；在降解过程中,浸泡液的pH值在6.4～7.4之间变化；复合材料在SBF中浸泡后,其表面能够沉积磷灰石,表明复合材料具有良好的生物活性,有利于植入体与骨组织形成良好的界面结合.
参考文献
| [1] | Pape H C,Evans A, Kobbe P. Autologous bone graft:Properties and techniques [J]. Journal of Orthopaedic Trauma,2010,24(S1):S36-S40. |
| [2] | Christopher G,Finkemeier M D.Bone-grafting and bonegraft substitutes[J].The Journal of Bone & Joint Surgery,2002,84(3):454-464. |
| [3] | 邱贵兴,孙世荃.同种异体骨植入材料的临床应用[J].中华骨科杂志,2004,24(10):635-637.Qiu Guixing, Sun Shiquan. Clinical application of bone allograft[J].Chinese Journal of Orthopaedics,2004,24(10):635-637. |
| [4] | 李玉宝.生物医学材料[M].北京:化学工业出版社,2003.Li Yubao. Biomedical materials[M]. Beijing: Chemical Industry Press,2003. |
| [5] | 应小樟,徐华梓.硫酸钙制剂在骨科的应用[J].国际骨科杂志,2006,27(2):86-88.Ying Xiaozhang,Xu Huazi.The application of calcium sulfate in the orthopaedic preparations[J].International Orthopaedic Magazine,2006,27(2):86-88. |
| [6] | 张杜娟,张丽芳,张志萍,等.骨修复复合材料CSH/BGs的制备及其性能研究[J].合成化学,2008,16(6):624-627.Zhang Dujuan, Zhang Lifang, Zhang Zhiping, et al.Preparation of bone repairing composite material CSH/BGs and its performance investigation[J]. Chinese Journal of Synthetic Chemistry,2008,16(6):624-627. |
| [7] | Nilsson M,Wang J S,Wielanek L,et al.Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute[J].J Bone Joint Surg Br,2004,86(1):120-125. |
| [8] | 张永莉,霍书娟,高建平,等.明胶/硫酸钙复合生物材料[J].高分子材料科学与工程,2006,22(1):215-217Zhang Yongli,Huo Shujuan,Gao Jianping,et al.CLGEL/CS composite biomaterial[J]. Polymer Materials Science and Engineering,2006,22(1):215-217. |
| [9] | 王振林,闫玉华,万涛.羟基磷灰石/胶原类骨仿生复合材料的制备及表征[J].复合材料学报,2005,22(2):83-86.Wang Zhenlin, Yan Yuhua, Wan Tao. Preparation and characterization of hydroxyapatite/collagen bone - like biomimetic composite[J].Acta Materiae Compositae Sinica,2005,22(2): 83-86. |
| [10] | 牛旭锋,冯庆玲,王明波,等.微囊化壳聚糖/纳米羟基磷灰石/胶原/聚乳酸复合材料[J].复合材料学报,2009,26(2):143-148.Niu Xufeng, Feng Qingling, Wang Mingbo, et al. Chitosan microspheres/nano-hydroxyapatite/collagen/polylactide composite[J].Acta Materiae Compositae Sinica,2009,26(2): 143-148. |
| [11] | 俞猛.骨组织工程支架材料修复骨缺损的特性[J].中国组织工程研究与临床康复,2010,14(47):8869-8872.Yu Meng.Characteristics of bone tissue engineering scaffold materials for repair of bone defects[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2010,14 (47):8869-8872. |
| [12] | Wang Xuejiang,Li Yubao, Wei Jie, et al. Development of biomimetic nano-hydroxyapatite/poly (hexamethylene adipamide)composites[J].Biomaterials,2002,23(24):4787-4791. |
| [13] | 李鸿,南景天,吕国玉,等.新型可降解α-TCP/多元氨基酸共聚物复合材料制备与表征[J].复合材料学报,2010,27(4):26-30.Li Hong,Nan Jingtian,Lü Guoyu,et al.Novel degradable α-TCP/multi (amino acid) copolymer composite:Preparation and characterization[J]. Acta Materiae Compositae Sinica,2010,27(4):26-30. |
| [14] | 张玉玲,黄君礼,程志辉,等.改性聚天冬氨酸的热缩共聚合成[J].现代化工,2006,26(3):43-45.Zhang Yuling,Huang Junli,Cheng Zhihui,et al.Thermal polycondensation synthesis of modified polyaspartic acid[J].Modern Chemical Industry,2006,26(3):43-45. |
| [15] | 朱凌,吴一弦,王玲玲,等.天冬氨酸与谷氨酸共聚反应研究[J].北京化工大学学报,2007,34(1):49-52.Zhu Ling, Wu Yixian, Wang Lingling, et al. The copolycondensation of L-aspartic acid and L glutamic acid[J].Journal of Beijing University of Chemical Technology,2007,34(1):49-52. |
| [16] | Schwamborn Michael. Chemical synthesis of polyaspartates:A biodegradable alternative to currently used polfcarboxylate homo-and copolymers[J].Polymer Degradation and Stability,1998,59(1-3):39-45. |
| [17] | 毛克亚,李江涛,杨云,等.β-TCP/α CSH复合植骨材料固化性能与力学强度[J].医用生物力学,2010,25(6):456-478.Mao Keya,Li Jiangtao,Yang Yun,et al.Study on the setting property and compressive strength of β-TCP/α CSH combined bone graft[J].Journal of Medical Biomechanics,2010,25(6):456-478. |
| [18] | Kokubo Tadashi,Takadama Hiroaki.How useful is SBF in predicting in vivo bone bioactivity?[J].Biomaterials,2006,27(15):2907-2915. |
| [19] | 程艳玲,赵玉娥,王海玉,等.生物降解型聚谷氨酸的研究进展[J].北京联合大学学报:自然科学版,2008,22(2):45-49.Cheng Yanling,Zhao Yu'e,Wang Haiyu,et al.Development of biodegradable polyglutamic acid[J]. Journal of Beijing Union University:Natural Sciences,2008,22(2):45-49. |
| [20] | 葛亮,苟三怀,杨四川,等.复合纳米人工骨的注射、凝固及其机械性能研究[J].生物骨科材料与临床研究,2006,3(5):4-8.Ge Liang,Gou Sanhuai,Yang Sichuan,et al.The injection,hardening and mechanical properties of a new composite nanobone substitute[J].Orthopaedic Biomechanics Materials and Clinicals,2006,3(5):4-8. |
| [21] | 张民,王建生,卫小春,等.可注射性硫酸钙/羟基磷灰石骨替代物抗压强度的影响因素[J].生物医学工程与临床,2006,10(3):135-137.Zhang Min,Wang Jiansheng,Wei Xiaochun,et al. Factors influencing the compressive strength of an injectable calcium sulphate-hydroxyapatite bone subsititutes[J]. Biomedical Engineering and Clinical Medicine,2006,10(3):135-137. |
| [22] | Safdar N K,Emre T,Joseph M L. Clinical applications of bone graft substitutes[J].Orthop Clin North Am,2000,31(3):389-398. |
| [23] | Spinelli A B,Ricci J L,Parsons J R. In vitro dissolution studies of calcium sulfate cements in simulated body fluid[C]//Procs 25th Annual Meeting of Society for Biomaterials.Providence,RI,USA: Society for Biomaterials,1999,344. |
| [24] | Turner TM, Urban R M, Gitelis S, et al. Resorption evaluation of a large bolus of calciumsulfate in a canine medullary defect[J].Orthopedics,2003,26(5):577-579. |
| [25] | Daveed D F,Vijay K L, Tobin N G, et al. Ex vivo degradation of a poly (propylene glycol - fumarate)biodegradable particulate composite bone cement [J]. J Biomed Mater Res,1997,35(3):383-389. |
| [26] | Lei Y,Rai B,Ho K H,et al.In vitro degradation of novel bioactive polycaprolactone: 20％ tricalcium phosphate composite scaffolds for bone engineering[J].Mater Sci Eng C,2007,27(2):293-298. |
| [27] | Orava E, Korventausta J, Rosenberg M, et al. In vitro degradation of porous poly (DL lactide-co-glycolide)(PLGA)/bioactive glass composite foams with a polar structure[J].Polymer Degradation and Stability,2007,92(1): 14-23. |
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