采用离子凝胶法制备了欧车前胶-g聚丙烯酸/凹凸棒黏土/海藻酸钠(PSY-g-PAA/APT/SA)载药复合凝胶小球,以双氯芬酸钠为模型药物,考察了pH敏感性和凹凸棒黏土含量对凝胶小球的包封率、载药率、溶胀性能和药物释放行为的影响.结果表明,当释放介质为模拟胃液(pH=1.2)时,药物基本不释放；而为模拟肠液(pH=6.8)时,5h后累积释放率超过90％,复合凝胶小球具有明显的pH敏感性.随着凝胶小球中凹凸棒黏土含量的增加,溶胀率和药物累积释放率均减小,表明凹凸棒黏土的引入可以减缓药物的突释效应.
参考文献
| [1] | 郑茂松;王爱勤;詹庚申.凹凸棒石黏土应用研究[M].北京:化学工业出版社,2007 |
| [2] | 马玉恒,方卫民,马小杰.凹凸棒土研究与应用进展[J].材料导报,2006(09):43-46. |
| [3] | 汤庆国,沈上越,梁金生,李养贤,王丽娟.磁性凹凸棒石靶向药物载体材料的制备及性能[J].硅酸盐学报,2006(01):93-97. |
| [4] | 汪琴,王文己,王爱勤.酸热处理凹凸棒石黏土对双氯芬酸钠的吸附及体外释放性能研究[J].中国矿业,2008(05):82-85,88. |
| [5] | 李平,魏琴,王爱勤.凹凸棒石对双氯芬酸钠的吸附作用与应用研究[J].中国生化药物杂志,2006(02):79-82. |
| [6] | Zhang Junping;Wang Qin;Wang Aiqin .In situ generation ot sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices[J].Acta Biomaterialia,2010,6(02):445. |
| [7] | Qin Wang;Junping Zhang;Aiqin Wang .Preparation and characterization of a novel pH-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2009(4):731-737. |
| [8] | Milton H.Fischer;Nanxiong Yu;Gary R.Gray;John Ralph;Laurens Anderson;Judith A.Marlett .The gel-forming polysaccharide of psyllium husk (Plantago ovata Forsk)[J].Carbohydrate research,2004(11):2009-2017. |
| [9] | Singh,B .Psyllium as therapeutic and drug delivery agent.[J].International Journal of Pharmaceutics,2007(1/2):1-14. |
| [10] | Baljit Singh;Nirmala Chauhan;S.Kumar .Radiation crosslinked psyllium and polyacrylic acid based hydrogels for use in colon specific drug delivery[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2008(3):446-455. |
| [11] | Baljit Singh;Nisha Sharma;Nirmala Chauhan .Synthesis,characterization and swelling studies of pH responsive psyllium and methacrylamide based hydrogels for the use in colon specific drug delivery[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2007(4):631-643. |
| [12] | An Jianke;Wang Wenbo;Wang Aiqin .Preparation and swelling properties of a pH-sensitive superabsorbent hydrogd based on psyllium gum[J].Starch-St(a)rke,2010,62(10):501. |
| [13] | Wang, Qin;Xie, Xiaoling;Zhang, Xiaowei;Zhang, Junping;Wang, Aiqin .Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2010(3):356-362. |
| [14] | 王巍;高鹏来;何红梅.中华人民共和国药典[M].北京:中国医药科技出版社,2010:85. |
| [15] | Peppas N A .Analysis of fickian and non fickian drug release from polymers[J].Pharmaceutica Acta Helvetiae,1985,60(04):110. |
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