采用配位开环聚合和偶合反应合成了设计相对分子质量为1.2万、1.5万和2万的聚环氧乙烷-聚乳酸-聚环氧乙烷(mPEO-b-PLLA-b-mPEO)两亲性三嵌段聚合物,利用核磁共振氢谱和凝胶渗透色谱表征了产物的相对分子质量及其分布.结果表明,产物相对分子质量与设计的相对分子质量基本一致,相对分子质量分布分别为1.15、1.15和1.27.透射电镜和激光纳米粒度分析仪测试结果表明,聚合物形成核壳状结构的胶束,粒径大小随着温度的升高先增大后减小.凝胶-溶胶转变相图结果表明,随着亲水、疏水链段比减小,临界凝胶-溶胶转变温度升高.
参考文献
| [1] | Prabaharan M;Mano JF .Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials[J].Macromolecular bioscience,2006(12):991-1008. |
| [2] | Kim MS;Seo KS;Khang G;Cho SH;Lee HB .Preparation of methoxy poly(ethylene glycol)/polyester diblock copolymers and examination of the gel-to-sol transition[J].Journal of Polymer Science, Part A. Polymer Chemistry,2004(22):5784-5793. |
| [3] | Ruan G;Feng SS .Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel.[J].Biomaterials,2003(27):5037-5044. |
| [4] | Zhang Y;Pan MG;Liu C;Huang JL .Preparation of amphiphilic ternary block copolymers with PEO as the middle block and the effect of PEO position on the glass transition temperature (T-g) of copolymers[J].Journal of Polymer Science, Part A. Polymer Chemistry,2008(8):2624-2631. |
| [5] | 王玉东,张孝彦,刘晓琼,付鹏,刘民英,赵清香.聚环氧乙烷-聚丙交酯嵌段共聚物的合成[J].郑州大学学报（工学版）,2011(02):26-28. |
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