聚二甲基硅氧烷(Polydimethylsiloxane,PDMS)由于具有良好的光学和化学性能,以及加工简单、价格便宜等优点,已广泛应用于微流控芯片研究领域.但PDMS的高疏水性以及它对如DNA、蛋白质等生物大分子具有较强的表面吸附特性,限制了它的应用范围.目前,基本上都是通过修饰的方法来改善PDMS表面亲水性能.按照PDMS经处理后恢复疏水性的时间长短,将PDMS表面修饰的方法分为暂时性修饰方法和永久性修饰方法;也可以按照对PDMS处理的原理分为物理修饰方法、化学修饰方法以及将两者相结合使用的方法.总之,各种方法都有很广泛的应用,实际处理时,仍要考虑到实验条件等因素的限制.概述了目前常用的几种针对PDMS表面修饰的方法,包括它们的基本原理、修饰效果以及相关应用研究.
参考文献
| [1] | Winzor D J .Determination of binding constants by analogous procedures in size exclusion chromatography and capillary electrophoresis[J].Analytical Biochemistry,2008,383(01):1. |
| [2] | Shin GW;Cho YS;Hwang HS;Park JH;Jung GY .A two-step quantitative pathogen detection system based on capillary electrophoresis[J].Analytical Biochemistry: An International Journal of Analytical and Preparative Methods,2008(1):31-37. |
| [3] | Mi-Hwa Oh;Young Seoub Park;Se-Hee Paek;Hae-Yeong Kim;Gyoo Yeol Jung;Sangsuk Oh .A rapid and sensitive method for detecting foodborne pathogens by capillary electrophoresis-based single-strand conformation polymorphism.[J].Food Control,2008(11):1100-1104. |
| [4] | Matsuda S;Ichitani K;Kanno M.Visualization of hydrogen diffusion path by a high sensitivity hydrogen microprint technique[M].Amsterdam:Elsevier,2008:239. |
| [5] | Yoshioka M et al.Analysis of hydrogen behaviour in crack growth tests of[gamms]-TiAl by means of the hydrogen microprint technique[J].Intermetallics,2004,12(01):23. |
| [6] | Miyaki K;Zeng HL;Nakagama T;Uchiyama K .Steady surface modification of polydimethylsiloxane microchannel and its application in simultaneous analysis of homocysteine and glutathione in human serum[J].Journal of chromatography, A: Including electrophoresis and other separation methods,2007(1/2):201-206. |
| [7] | Bar G.;Hafele A.;Whangbo MH.;Delineau L. .Investigation of the stiffness change in, the indentation force and the hydrophobic recovery of plasma-oxidized polydimethylsiloxane surfaces by tapping mode atomic force microscopy[J].Polymer: The International Journal for the Science and Technology of Polymers,2001(8):3627-3632. |
| [8] | Hsien-Yeh Chen;Arthur A.McClelland;Zhan Chen .Solventless Adhesive Bonding Using Reactive Polymer Coatings[J].Analytical chemistry,2008(11):4119-4124. |
| [9] | Belder D;Ludwig M .Surface modification in microchip electrophoresis.[J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2003(21):3595-3606. |
| [10] | Makamba H;Kim JH;Lim K;Park N;Hahn JH .Surface modification of poly(dimethylsiloxane) microchannels.[J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2003(21):3607-3619. |
| [11] | Abhasi F;Mirzadeh H;Katbab A A .Bulk and surface modification of silicone rubber for biomedical applications[J].Polymer International,2002,51:882. |
| [12] | Xiao Y;Yu XD;Xu JJ;Chen HY .Bulk modification of PDMS microchips by an amphiphilic copolymer.[J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2007(18):3302-3307. |
| [13] | Aerts S;Vanhulsel A;Buekenhoudt A et al.Plasma-treated PDMS-membranes in solvent resistant nanofiltration:Characterization and study of transport mechanism[J].Journal of Membrane Science,2006,275(1-2):212. |
| [14] | Dhananjay Bodas;Chantal Khan-Malek .Hydrophilization and hydrophobic recovery of PDMS by oxygen plasma and chemical treatment-An SEM investigation[J].Sensors and Actuators, B. Chemical,2007(1):368-373. |
| [15] | Bodas D;Khan-Malek C .Formation of more stable hydrophilic surfaces of PDMS by plasma and chemical treatments[J].Microelectronic Engineering,2006,83(4-9):1277. |
| [16] | Olah A;Hillborg H;Vancso GJ .Hydrophobic recovery of UV/ozone treated poly(dimethylsiloxane): adhesion studies by contact mechanics and mechanism of surface modification[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,2005(3/4):410-423. |
| [17] | Efimenko K.;Wallace WE.;Genzer J. .Surface modification of Sylgard-184 poly(dimethyl siloxane) networks by ultraviolet and ultraviolet/ozone treatment[J].Journal of Colloid and Interface Science,2002(2):306-315. |
| [18] | Schnyder B.;Lippert T.;Kotz R.;Wokaun A.;Graubner VM.;Nuyken O. .UV-irradiation induced modification of PDMS films investigated by XPS and spectroscopic ellipsometry[J].Surface Science: A Journal Devoted to the Physics and Chemistry of Interfaces,2003(0):1067-1071. |
| [19] | Berdichevsky Y;Khandurina J;Guttman A et al.UV/ozone modification of poly(dimethylsiloxane)microfluidic channels[J].Sens Actuators B:Chem,2004,97(2-3):402. |
| [20] | Khorasani M T;Mirzadeh H;San-lrnes P G .Laser surface modification of polymers to improve biocompatibility:HEMA grafted PDMS,in vitro assay-Ⅲ[J].Radiation Physics and Chemistry,1999,55(5-6):685. |
| [21] | Goddard J M;Hotchkiss J H .Polymer surfaca modification for the attachment of bioactive compounds[J].Progress in Polymer Science,2007,32(07):698. |
| [22] | Grunwald H;Adam R;Bartella J et al.Better aluminium mirrors by integrating plasma pretreatment,sputtering,and plasma polymerization for large-scale car headlight production[J].Surface and Coatings Technology,1999,111(2-3):287. |
| [23] | Houston KS.;Weinkauf DH.;Stewart FF. .Gas transport characteristics of plasma treated poly (dimethylsiloxane) and polyphosphazene membrane materials[J].Journal of Membrane Science,2002(1/2):103-112. |
| [24] | Behnisch J.;Gazicki M.;Pela I.;Hollander A.;Ledzion R.;Tyczkowski J. .Formation of hydrophobic layers on biologically degradable polymeric foils by plasma polymerization[J].Surface & Coatings Technology,1998(1/3):872-874. |
| [25] | Favia P.;d'Agostino R. .Plasma treatments and plasma deposition of polymers for biomedical applications[J].Surface & Coatings Technology,1998(1/3):1102-1106. |
| [26] | Sadhir R K et al.Plasma deposited thin films sui-table as moisture sensors[J].Journal of Materials Science,1991,26(16):4261. |
| [27] | Bodo P;Sundgren J E .Titanium deposition onto ion-bombarded and plasma-treated polydimethylsiloxane:Surface modification,interface and adhesion[J].Thin Solid Films,1986,136(01):147. |
| [28] | Gaboury S R;Urban M W .Quantitative analysis of the SiH groups formed on poly(dimethylsiloxane)surfaces:An ATR FTIR approach[J].POLYMER,1992,33(23):5085. |
| [29] | Graubner VM.;Jordan R.;Nuyken O.;Lippert T.;Hauer M.;Schnyder B. Wokaun A. .Incubation and ablation behavior of poly(dimethylsiloxane) for 266 nm irradiation[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,2002(0):786-790. |
| [30] | Drew M.Fluid surfaces and interfaces[A]//Surfactant science and technology[M].Singapore:Wiley Services,2005:80. |
| [31] | Seo J;Lee LP .Effects on wettability by surfactant accumulation/depletion in bulk polydimethylsiloxane (PDMS)[J].Sensors and Actuators, B. Chemical,2006(1):192-198. |
| [32] | Wang A J;Xu J J;Chen H Y .Nonionic surfactant dynamic coating of poly(dimethylsiloxane)channel surface for microchip electrophoresis of amino acids[J].Analytica Chimica Acta,2006,569(1-2):188. |
| [33] | Aziz T;Waters M;Jagger R .Surface modification of an experimental silicone rubber maxillofacial material to improve wettability.[J].Journal of dentistry,2003(3):213-216. |
| [34] | Uyama Y;Kato K;Ikada Y.Surface modification of polymers by grafting[M].Berlin:springer-verlag,1998:1. |
| [35] | Seunghwan Lee;Janos Voros .An Aqueous-Based Surface Modification of poly(dimethylsiloxane)with poly(ethylene glycol)to Prevent Biofouling[J].Langmuir: The ACS Journal of Surfaces and Colloids,2005(25):11957-11962. |
| [36] | 陆振华 .微流控免疫层析检测芯片的研制[D].中国科学院上海微系统与信息技术研究所,2007. |
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