采用溶液聚合法制备了改性的聚甲基丙烯酸树脂, 作为支架表面载药涂层的药物载体聚合物. 采用浸涂法制备了不锈钢基体表面聚合物及聚合物载药涂层, 并利用红外光谱及核磁共振波谱分析了所制备共聚物的成分, 并评价了物理性能、 生物稳定性能以及药物的释放性能. 结果表明, 所制备的涂层具有较好的生物稳定性, 甲基丙烯酸和甲基丙烯酸丁酯的加入提高了聚合物的物理性能, 尤其是涂层与金属基体的结合力. 所制备的药物释放涂层具有缓释紫杉醇的功能, 其释放周期超过15 d. 聚甲基丙烯酸树脂携带紫杉醇的载药涂层在生物稳定性、 物理性能及药物释放性能方面满足冠脉支架的表面涂层的使用要求.
Solution polymerisation was employed to prepare the modified polymethacrylate resin as the polymer for coating on coronary stents with drug elusion. Both the polymer and the drug elusion coatings on the stainless steel were prepared by the dipping technology. The composition of copolymer was analyzed by IR and NMR techniques, and the physical property, the biostability and the drug elusion characteristic were also evaluated by Ultro--spectrophotometer, HPLC. The results show that the modified polymethacrylate resin has favorable biostability, and the addition of MAA and BMA provides the polymer with improved physical property, especially the adhesive force between the polymer coating and the stainless steel substrate. The drug elusion coating has paclitaxol releasing function, and its releasing time is more than 15 days. The manufactured paclitaxol--releasing polymethacrylate resin coating can be used as the coronary stent coating.
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